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dc.contributor.authorShameer, Sanu
dc.contributor.authorLogan-Klumpler, Flora J
dc.contributor.authorVinson, Florence
dc.contributor.authorCottret, Ludovic
dc.contributor.authorMerlet, Benjamin
dc.contributor.authorAchcar, Fiona
dc.contributor.authorBoshart, Michael
dc.contributor.authorBerriman, Matthew
dc.contributor.authorBreitling, Rainer
dc.contributor.authorBringaud, Frédéric
dc.contributor.authorBütikofer, Peter
dc.contributor.authorCattanach, Amy M
dc.contributor.authorBannerman-Chukualim, Bridget
dc.contributor.authorCreek, Darren J
dc.contributor.authorCrouch, Kathryn
dc.contributor.authorde Koning, Harry P
dc.contributor.authorDenise, Hubert
dc.contributor.authorEbikeme, Charles
dc.contributor.authorFairlamb, Alan H
dc.contributor.authorFerguson, Michael A J
dc.contributor.authorGinger, Michael L
dc.contributor.authorHertz-Fowler, Christiane
dc.contributor.authorKerkhoven, Eduard J
dc.contributor.authorMäser, Pascal
dc.contributor.authorMichels, Paul A M
dc.contributor.authorNayak, Archana
dc.contributor.authorNes, David W
dc.contributor.authorNolan, Derek P
dc.contributor.authorOlsen, Christian
dc.contributor.authorSilva-Franco, Fatima
dc.contributor.authorSmith, Terry K
dc.contributor.authorTaylor, Martin C
dc.contributor.authorTielens, Aloysius G M
dc.contributor.authorUrbaniak, Michael D
dc.contributor.authorvan Hellemond, Jaap J
dc.contributor.authorVincent, Isabel M
dc.contributor.authorWilkinson, Shane R
dc.contributor.authorWyllie, Susan
dc.contributor.authorOpperdoes, Fred R
dc.contributor.authorBarrett, Michael P
dc.contributor.authorJourdan, Fabien
dc.date.accessioned2014-11-19T16:31:03Z
dc.date.available2014-11-19T16:31:03Z
dc.date.issued2015-01-28
dc.identifier.citationShameer , S , Logan-Klumpler , F J , Vinson , F , Cottret , L , Merlet , B , Achcar , F , Boshart , M , Berriman , M , Breitling , R , Bringaud , F , Bütikofer , P , Cattanach , A M , Bannerman-Chukualim , B , Creek , D J , Crouch , K , de Koning , H P , Denise , H , Ebikeme , C , Fairlamb , A H , Ferguson , M A J , Ginger , M L , Hertz-Fowler , C , Kerkhoven , E J , Mäser , P , Michels , P A M , Nayak , A , Nes , D W , Nolan , D P , Olsen , C , Silva-Franco , F , Smith , T K , Taylor , M C , Tielens , A G M , Urbaniak , M D , van Hellemond , J J , Vincent , I M , Wilkinson , S R , Wyllie , S , Opperdoes , F R , Barrett , M P & Jourdan , F 2015 , ' TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei ' , Nucleic Acids Research , vol. 43 , pp. D637-D644 . https://doi.org/10.1093/nar/gku944en
dc.identifier.issn0305-1048
dc.identifier.otherPURE: 155539558
dc.identifier.otherPURE UUID: 6a1302a3-9cf0-4446-b5bc-d61eb4a0a3c4
dc.identifier.otherPubMed: 25300491
dc.identifier.otherScopus: 84943153611
dc.identifier.otherWOS: 000350210400095
dc.identifier.urihttps://hdl.handle.net/10023/5801
dc.descriptionEuropean Commission FP7 Marie Curie Initial Training Network ‘ParaMet’ [290080 to S.S.]; ANR project MetaboHub [ANR-11-INBS-0010 to B.M.]; Wellcome Trust [085349]; The work of Fiona Achcar was part of the SysMO SilicoTryp project coordinated by R.B. Funding for open access charge: European Commission FP7 Marie Curie Initial Training Network ‘ParaMet’ [290080].en
dc.description.abstractThe metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our understanding of individual metabolic networks is increasing as we learn more about the enzymes that are active in particular cells under particular conditions and as technologies advance to allow detailed measurements of the cellular metabolome. Metabolic network databases are of increasing importance in allowing us to contextualise data sets emerging from transcriptomic, proteomic and metabolomic experiments. Here we present a dynamic database, TrypanoCyc (http://www.metexplore.fr/trypanocyc/), which describes the generic and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible for human and animal African trypanosomiasis. In addition to enabling navigation through the BioCyc-based TrypanoCyc interface, we have also implemented a network-based representation of the information through MetExplore, yielding a novel environment in which to visualise the metabolism of this important parasite.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofNucleic Acids Researchen
dc.rights© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.subjectQH301 Biologyen
dc.subjectDASen
dc.subject.lccQH301en
dc.titleTrypanoCyc : a community-led biochemical pathways database for Trypanosoma bruceien
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1093/nar/gku944
dc.description.statusPeer revieweden


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