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dc.contributor.authorJohnston, I.A.
dc.contributor.authorGarcia de la Serrana Castillo, Daniel
dc.contributor.authorDevlin, R.H.
dc.date.accessioned2014-11-19T11:31:02Z
dc.date.available2014-11-19T11:31:02Z
dc.date.issued2014-10-01
dc.identifier.citationJohnston , I A , Garcia de la Serrana Castillo , D & Devlin , R H 2014 , ' Muscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormone ' , Journal of Experimental Biology , vol. 217 , no. 19 , pp. 3392-3395 . https://doi.org/10.1242/jeb.107664en
dc.identifier.issn0022-0949
dc.identifier.otherPURE: 157758108
dc.identifier.otherPURE UUID: 03de10e3-ddcf-487c-b682-57acab99dec0
dc.identifier.otherScopus: 84908542364
dc.identifier.otherORCID: /0000-0002-7796-5754/work/47136038
dc.identifier.otherWOS: 000342506700008
dc.identifier.urihttp://hdl.handle.net/10023/5798
dc.descriptionThe study was supported by the Marine Alliance for Science and Technology for Scotland (Scottish Funding Council grant HR09011) and by the Canadian Biotechnology Strategy (to R.H.D.). Deposited in PMC for immediate releaseen
dc.description.abstractCoho salmon (Oncorhynchus kisutch) transgenic for growth hormone (GH) show substantially faster growth than wild-type (WT) fish. We fed GH-transgenic salmon either to satiation (1 year; TF) or the same smaller ration of wild-type fish (2 years; TR), resulting in groups matched for body size to WT salmon. The myotomes of TF and WT fish had the same number and size distribution of muscle fibres, indicating a twofold higher rate of fibre recruitment in the GH transgenics. Unexpectedly, calorie restriction was found to decrease the rate of fibre production in transgenics, resulting in a 20% increase in average fibre size and reduced costs of ionic homeostasis. Genes for myotube formation were downregulated in TR relative to TF and WT fish. We suggest that muscle fibre size optimisation allows the reallocation of energy from maintenance to locomotion, explaining the observation that calorie-restricted transgenics grow at the same rate as WT fish whilst exhibiting markedly higher foraging activity.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofJournal of Experimental Biologyen
dc.rights© 2014. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.en
dc.subjectGrowthen
dc.subjectMyotube formationen
dc.subjectTransgenesisen
dc.subjectOptimal fibre size hypothesisen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleMuscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormoneen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews.Centre for Research into Ecological & Environmental Modellingen
dc.identifier.doihttps://doi.org/10.1242/jeb.107664
dc.description.statusPeer revieweden


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