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dc.contributor.authorZagoraiou, L
dc.contributor.authorAkay, T
dc.contributor.authorMartin, J F
dc.contributor.authorBrownstone, R M
dc.contributor.authorJessell, T M
dc.contributor.authorMiles, Gareth Brian
dc.identifier.citationZagoraiou , L , Akay , T , Martin , J F , Brownstone , R M , Jessell , T M & Miles , G B 2009 , ' A cluster of cholinergic premotor interneurons modulates mouse locomotor activity ' , Neuron , vol. 64 , no. 5 , pp. 645-662 .
dc.identifier.otherPURE: 467925
dc.identifier.otherPURE UUID: 680c4259-30c0-42dc-9cba-91d4d6dbf3f7
dc.identifier.otherstandrews_research_output: 32039
dc.identifier.otherScopus: 71149108487
dc.identifier.otherWOS: 000273123700011
dc.identifier.otherORCID: /0000-0002-8624-4625/work/29135011
dc.description.abstractMammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive prominent “C bouton” cholinergic inputs from spinal interneurons, but the source and function of these synaptic inputs have remained obscure. We show here that the transcription factor Pitx2 marks a small cluster of spinal cholinergic interneurons, V0C neurons, that represents the sole source of C bouton inputs to motor neurons. The activity of these cholinergic interneurons is tightly phase locked with motor neuron bursting during fictive locomotor activity, suggesting a role in the modulation of motor neuron firing frequency. Genetic inactivation of the output of these neurons impairs a locomotor task-dependent increase in motor neuron firing and muscle activation. Thus, V0C interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior.
dc.rightsCopyright © 2009 Elsevier Ltd. Published under an Elsevier user license. Users may access, download, copy, translate, text mine and data mine the articles under terms available at
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleA cluster of cholinergic premotor interneurons modulates mouse locomotor activityen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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