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dc.contributor.authorKelsey, Thomas W
dc.contributor.authorLi, Lucy Q
dc.contributor.authorMitchell, Rod T
dc.contributor.authorWhelan, Ashley
dc.contributor.authorAnderson, Richard A
dc.contributor.authorWallace, W Hamish B
dc.identifier.citationKelsey , T W , Li , L Q , Mitchell , R T , Whelan , A , Anderson , R A & Wallace , W H B 2014 , ' A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years ' , PLoS One , vol. 9 , no. 10 , e109346 .
dc.identifier.otherPURE: 154954685
dc.identifier.otherPURE UUID: 7eaa63de-7f5b-42dc-a6af-69c9773806cb
dc.identifier.otherPubMed: 25295520
dc.identifier.otherScopus: 84907833256
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201538
dc.identifier.otherWOS: 000345204000061
dc.description.abstractThe diagnosis of hypogonadism in human males includes identification of low serum testosterone levels, and hence there is an underlying assumption that normal ranges of testosterone for the healthy population are known for all ages. However, to our knowledge, no such reference model exists in the literature, and hence the availability of an applicable biochemical reference range would be helpful for the clinical assessment of hypogonadal men. In this study, using model selection and validation analysis of data identified and extracted from thirteen studies, we derive and validate a normative model of total testosterone across the lifespan in healthy men. We show that total testosterone peaks [mean (2.5-97.5 percentile)] at 15.4 (7.2-31.1) nmol/L at an average age of 19 years, and falls in the average case [mean (2.5-97.5 percentile)] to 13.0 (6.6-25.3) nmol/L by age 40 years, but we find no evidence for a further fall in mean total testosterone with increasing age through to old age. However we do show that there is an increased variation in total testosterone levels with advancing age after age 40 years. This model provides the age related reference ranges needed to support research and clinical decision making in males who have symptoms that may be due to hypogonadism.
dc.relation.ispartofPLoS Oneen
dc.rights© 2014. Kelsey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectR Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleA validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 yearsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.description.statusPeer revieweden

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