Is it worthwhile to conduct a randomized controlled trial of glaucoma screening in the United Kingdom?
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Objectives To assess the value of conducting a glaucoma screening randomized controlled trial in the UK. Methods Decision model based economic evaluation and value of information analysis. Model derived from a previous health technology assessment. Model updated in terms of structure and parameter estimates with data from surveys, interviews with members of the public and health care providers and routine sources. Results On average, across a range of ages of initiating screening (40–60 years), glaucoma prevalence (1–5%), screening uptake (30–100%), and the performance of current case finding, screening was not cost-effective at a £30,000 threshold per quality adjusted life year (QALY) from the perspective of the National Health Service (NHS). The societal value of removing all uncertainty around glaucoma screening is £107 million at a threshold of £20,000 per QALY. For informing policy decisions on glaucoma screening, reducing uncertainty surrounding the NHS and personal social care cost of sight impairment (£74 million) was of most value, followed by reducing uncertainty in test performance (£14 million) and uptake of either screening or current eye care (£8 million each). Conclusions A glaucoma screening trial in the UK is unlikely to be the best use of research resources. Further research to quantify the costs of sight impairment falling on the NHS and personal social services is a priority. Further development of glaucoma tests and research into strategies to promote the uptake of screening or current eye care such as through the use of a behavioural intervention would be worthwhile.
Burr , J , Hernández , R , Ramsay , C , Prior , M , Campbell , S , Azuara-Blanco , A , Campbell , M , Francis , J & Vale , L 2014 , ' Is it worthwhile to conduct a randomized controlled trial of glaucoma screening in the United Kingdom? ' Journal of health services research & policy , vol 19 , no. 1 , pp. 42-51 . DOI: 10.1177/1355819613499748
Journal of health services research & policy
Copyright The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
This paper was developed from a strategic grant funded by the Medical Research Council (project reference G0701759).
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