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dc.contributor.authorCizmar, Tomas
dc.contributor.authorDholakia, Kishan
dc.contributor.editorMahadevanJansen, A
dc.contributor.editorVoDinh, T
dc.contributor.editorGrundfest, WS
dc.date.accessioned2014-09-19T09:31:02Z
dc.date.available2014-09-19T09:31:02Z
dc.date.issued2013-03-22
dc.identifier.citationCizmar , T & Dholakia , K 2013 , Exploiting multimode waveguides for pure fibre based fluorescence imaging . in A MahadevanJansen , T VoDinh & WS Grundfest (eds) , Advanced Biomedical and Clinical Diagnostic Systems XI . vol. 8572 , Proceedings of SPIE , vol. 8572 , SPIE , Bellingham , Conference on Advanced Biomedical and Clinical Diagnostic Systems XI , Canada , 3/02/13 . https://doi.org/10.1117/12.2003798en
dc.identifier.citationconferenceen
dc.identifier.issn0277-786X
dc.identifier.otherPURE: 149507032
dc.identifier.otherPURE UUID: a4a73a40-2c1f-4a46-8954-fde84655a7a5
dc.identifier.otherWOS: 000337082600017
dc.identifier.otherScopus: 84877844125
dc.identifier.urihttps://hdl.handle.net/10023/5453
dc.descriptionK. D. acknowledges support from EPSRC.en
dc.description.abstractThere has been an immense drive in modern microscopy towards miniaturisation and fibre based technology. This has been necessitated by the need to access hostile or difficult environments particularly in-situ and in-vivo. Strategies to date have included the use of specialist fibres and miniaturised scanning systems accompanied by ingenious microfabricated lenses. In parallel recent studies of randomized light fields and their holographic control opened up new ways for imaging. We present a novel approach for this field by utilising disordered light within a standard multimode optical fibre for minimally invasive lensless microscopy and optical mode conversion. We demonstrate scanning fluorescence microscopy at acquisition rates allowing observation of dynamic processes such as Brownian motion of mesoscopic particles. As the sample plane can be defined at any distance from the fibre facet, we eliminate the need for complex or elaborate focusing optics (e.g. miniaturized objectives, GRIN lenses) and instead reconfigure the system dynamically to image different axial planes. Furthermore, we show how such control can realise a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre based implementations of super-resolution or light sheet microscopy. To the best of our knowledge, this technology represents the narrowest possible image guiding system based on light propagation.
dc.format.extent7
dc.language.isoeng
dc.publisherSPIE
dc.relation.ispartofAdvanced Biomedical and Clinical Diagnostic Systems XIen
dc.relation.ispartofseriesProceedings of SPIEen
dc.rightsCopyright 2013 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.en
dc.subjectDigital holographyen
dc.subjectMultimode waveguidesen
dc.subjectFluorescenceen
dc.subjectMicroscopyen
dc.subjectLighten
dc.subjectResolutionen
dc.subjectQC Physicsen
dc.subjectR Medicine (General)en
dc.subject.lccQCen
dc.subject.lccR1en
dc.titleExploiting multimode waveguides for pure fibre based fluorescence imagingen
dc.typeConference itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1117/12.2003798


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