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dc.contributor.authorParker, D. J.
dc.contributor.authorGardiner, A.
dc.contributor.authorNeville, M. C.
dc.contributor.authorRitchie, M. G.
dc.contributor.authorGoodwin, S. F.
dc.date.accessioned2014-08-31T23:01:37Z
dc.date.available2014-08-31T23:01:37Z
dc.date.issued2014-03
dc.identifier106251902
dc.identifier2bac1d73-9219-48b2-be8c-8e54b36c0670
dc.identifier000331626500010
dc.identifier84894033872
dc.identifier000331626500010
dc.identifier.citationParker , D J , Gardiner , A , Neville , M C , Ritchie , M G & Goodwin , S F 2014 , ' The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons ' , Heredity , vol. 112 , no. 3 , pp. 300-306 . https://doi.org/10.1038/hdy.2013.106en
dc.identifier.issn0018-067X
dc.identifier.otherORCID: /0000-0001-7913-8675/work/46761141
dc.identifier.urihttps://hdl.handle.net/10023/5300
dc.description.abstractThere has been much debate concerning whether cis-regulatory or coding changes are more likely to produce evolutionary innovation or adaptation in gene function, but an additional complication is that some genes can dramatically diverge through alternative splicing, increasing the diversity of gene function within a locus. The fruitless gene is a major transcription factor with a wide range of pleiotropic functions, including a fundamental conserved role in sexual differentiation, species-specific morphology and an important influence on male sexual behaviour. Here, we examine the structure of fruitless in multiple species of Drosophila, and determine the patterns of selective constraint acting across the coding region. We found that the pattern of selection, estimated from the ratio of non-synonymous to synonymous substitutions, varied considerably across the gene, with most regions of the gene evolutionarily conserved but with several regions showing evidence of divergence as a result of positive selection. The regions that showed evidence of positive selection were found to be localised to relatively consistent regions across multiple speciation events, and are associated with alternative splicing. Alternative splicing may thus provide a route to gene diversification in key regulatory loci.
dc.format.extent7
dc.format.extent438793
dc.language.isoeng
dc.relation.ispartofHeredityen
dc.subjectDrosophilaen
dc.subjectfruen
dc.subjectgene diversityen
dc.subjectalternative splicingen
dc.subjectpositive selectionen
dc.subjectSex-determination geneen
dc.subjectZinc-Finger Proteinsen
dc.subjectDetermination Pathwayen
dc.subjectStatistical methodsen
dc.subjectAdaptive Evolutionen
dc.subjectCandidate Genesen
dc.subjectCourtship songen
dc.subjectBTB Domainen
dc.subjectBehavioren
dc.subjectMelanogasteren
dc.subjectQH Natural historyen
dc.subject.lccQHen
dc.titleThe evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exonsen
dc.typeJournal articleen
dc.contributor.sponsorNERCen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doi10.1038/hdy.2013.106
dc.description.statusPeer revieweden
dc.date.embargoedUntil2014-09-01
dc.identifier.grantnumberNE/J020818/1en


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