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dc.contributor.authorIliodromiti, Stamatina
dc.contributor.authorKelsey, Tom
dc.contributor.authorAnderson, Richard
dc.contributor.authorNelson, Scott
dc.date.accessioned2014-08-15T11:01:01Z
dc.date.available2014-08-15T11:01:01Z
dc.date.issued2013-08
dc.identifier48125943
dc.identifier3ca89bba-e6d1-4bc8-a8e9-653090d4361d
dc.identifier84881527371
dc.identifier.citationIliodromiti , S , Kelsey , T , Anderson , R & Nelson , S 2013 , ' Can Anti-Müllerian hormone predict the diagnosis of polycystic ovary syndrome? A systematic review and meta-analysis of extracted data ' , Journal of Clinical Endocrinology & Metabolism , vol. 98 , no. 8 , pp. 3332-3340 . https://doi.org/10.1210/jc.2013-1393en
dc.identifier.issn0021-972X
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201551
dc.identifier.urihttps://hdl.handle.net/10023/5171
dc.description.abstractContext: Existing biochemical tests for polycystic ovary syndrome (PCOS) have poor sensitivity and specificity. Many women with PCOS have high anti-Müllerian hormone (AMH) concentrations; thus, this may be a useful addition to the diagnostic criteria. Objective: A systematic literature review was performed to assess the true accuracy of AMH in the prediction of PCOS and to determine the optimal diagnostic threshold. Data Sources: Published and gray literature were searched for all years until January 2013. Study Selection: Observational studies defining PCOS according to the Rotterdam criteria and assessing the value of AMH in diagnosing PCOS were selected. Ten studies of the initial 314 hits reporting AMH values in the diagnosis of PCOS were included in the meta-analysis and the construction of the summary receiver-operating characteristic curve. Four studies that plotted individual AMH serum levels of women with PCOS and controls on graphs were selected for individual data extraction. Data Extraction: Two researchers independently assessed the abstracts resulted from the initial search against the inclusion criteria, graded the papers for selection and verification biases, and selected the papers that assessed the value of AMH in diagnosing PCOS. Data were extracted from 4 studies with the plotted individual data on graphs with the help of computer software. Data Synthesis: The meta-analysis of the extracted data demonstrated the specificity and sensitivity in diagnosing PCOS in the symptomatic women of 79.4% and 82.8%, respectively, for a cutoff value of AMH of 4.7 ng/mL. The area under the curve was 0.87 (95% confidence interval 0.83–0.92), identical with the area under the curve of 0.87 for the summary receiver-operating characteristic curve involving 10 separate studies. Conclusions: AMH may be a useful initial diagnostic test for PCOS subject to validation in prospective population cohorts.
dc.format.extent9
dc.format.extent1251223
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolismen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleCan Anti-Müllerian hormone predict the diagnosis of polycystic ovary syndrome? : A systematic review and meta-analysis of extracted dataen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.identifier.doihttps://doi.org/10.1210/jc.2013-1393
dc.description.statusPeer revieweden
dc.identifier.urlhttp://jcem.endojournals.org/content/early/2013/06/14/jc.2013-1393.abstracten
dc.identifier.grantnumberEP/H004092/1en


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