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Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod- shaped virus 2

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gardner2014jvirol7105.pdf (761.7Kb)
Date
01/06/2014
Author
Gardner, A.F.
Bell, S.D.
White, M.F.
Prangishvili, D.
Krupovic, M.
Keywords
QH301 Biology
Metadata
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Abstract
Viruses infecting hyperthermophilic archaea typically do not encode DNA polymerases, raising questions regarding their genome replication. Here, using a yeast two-hybrid approach, we have assessed interactions between proteins of Sulfolobus islandicus rod-shaped virus 2 (SIRV2) and the host-encoded proliferating cell nuclear antigen (PCNA), a key DNA replication protein in archaea. Five SIRV2 proteins were found to interact with PCNA, providing insights into the recruitment of host replisome for viral DNA replication.
Citation
Gardner , A F , Bell , S D , White , M F , Prangishvili , D & Krupovic , M 2014 , ' Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod- shaped virus 2 ' , Journal of Virology , vol. 88 , no. 12 , pp. 7105-7108 . https://doi.org/10.1128/JVI.00636-14
Publication
Journal of Virology
Status
Peer reviewed
DOI
https://doi.org/10.1128/JVI.00636-14
ISSN
0022-538X
Type
Journal article
Rights
© 2014. American Society for Microbiology.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/5037

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