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Presence and significant determinants of cognitive impairment in a large sample of patients with Multiple Sclerosis
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dc.contributor.author | Borghi, Martina | |
dc.contributor.author | Cavallo, Marco | |
dc.contributor.author | Carletto, Sara | |
dc.contributor.author | Ostacoli, Luca | |
dc.contributor.author | Zuffranieri, Marco | |
dc.contributor.author | Picci, Rocco Luigi | |
dc.contributor.author | Scavelli, Francesco | |
dc.contributor.author | Johnston, Harriet | |
dc.contributor.author | Furlan, Pier Maria | |
dc.contributor.author | Bertolotto, Antonio | |
dc.contributor.author | Malucchi, Simona | |
dc.date.accessioned | 2014-07-10T14:31:12Z | |
dc.date.available | 2014-07-10T14:31:12Z | |
dc.date.issued | 2013-07-29 | |
dc.identifier | 131097258 | |
dc.identifier | 94a67ef1-2b07-475d-bb68-72449b28d0a8 | |
dc.identifier | 000323369700083 | |
dc.identifier | 84880782725 | |
dc.identifier.citation | Borghi , M , Cavallo , M , Carletto , S , Ostacoli , L , Zuffranieri , M , Picci , R L , Scavelli , F , Johnston , H , Furlan , P M , Bertolotto , A & Malucchi , S 2013 , ' Presence and significant determinants of cognitive impairment in a large sample of patients with Multiple Sclerosis ' , PLoS One , vol. 8 , no. 7 , e69820 . https://doi.org/10.1371/journal.pone.0069820 | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/10023/5008 | |
dc.description | This work was supported by FISM - Fondazione Italiana Sclerosi Multipla (www.aism.it) - Cod. 2009/R/17. | en |
dc.description.abstract | Objectives: To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS. Methods: 303 patients with MS and 279 healthy controls were administered the Brief Repeatable Battery of Neuropsychological tests (BRB-N); measures of pre-morbid verbal competence and neuropsychiatric measures were also administered. Results: Patients and healthy controls were matched for age, gender, education and pre-morbid verbal Intelligence Quotient. Patients presenting with cognitive impairment were 108/303 (35.6%). In the overall group of participants, the significant predictors of the most sensitive BRB-N scores were: presence of MS, age, education, and Vocabulary. The significant predictors when considering MS patients only were: course of MS, age, education, vocabulary, and depression. Using logistic regression analyses, significant determinants of the presence of cognitive impairment in relapsing-remitting MS patients were: duration of illness (OR = 1.053, 95% CI = 1.010-1.097, p = 0.015), Expanded Disability Status Scale score (OR = 1.247, 95% CI = 1.024-1.517, p = 0.028), and vocabulary (OR = 0.960, 95% CI = 0.936-0.984, p = 0.001), while in the smaller group of progressive MS patients these predictors did not play a significant role in determining the cognitive outcome. Conclusions: Our results corroborate the evidence about the presence and the nature of cognitive impairment in a large sample of patients with MS. Furthermore, our findings identify significant clinical and demographic determinants of cognitive impairment in a large sample of MS patients for the first time. Implications for further research and clinical practice were discussed. | |
dc.format.extent | 9 | |
dc.format.extent | 170411 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS One | en |
dc.subject | Brief repeatable battery | en |
dc.subject | Scale | en |
dc.subject | Speed | en |
dc.subject | Population | en |
dc.subject | Relevance | en |
dc.subject | Deficits | en |
dc.subject | Memory | en |
dc.subject | MS | en |
dc.subject | R Medicine | en |
dc.subject.lcc | R | en |
dc.title | Presence and significant determinants of cognitive impairment in a large sample of patients with Multiple Sclerosis | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.identifier.doi | 10.1371/journal.pone.0069820 | |
dc.description.status | Peer reviewed | en |
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