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dc.contributor.authorBorghi, Martina
dc.contributor.authorCavallo, Marco
dc.contributor.authorCarletto, Sara
dc.contributor.authorOstacoli, Luca
dc.contributor.authorZuffranieri, Marco
dc.contributor.authorPicci, Rocco Luigi
dc.contributor.authorScavelli, Francesco
dc.contributor.authorJohnston, Harriet
dc.contributor.authorFurlan, Pier Maria
dc.contributor.authorBertolotto, Antonio
dc.contributor.authorMalucchi, Simona
dc.date.accessioned2014-07-10T14:31:12Z
dc.date.available2014-07-10T14:31:12Z
dc.date.issued2013-07-29
dc.identifier131097258
dc.identifier94a67ef1-2b07-475d-bb68-72449b28d0a8
dc.identifier000323369700083
dc.identifier84880782725
dc.identifier.citationBorghi , M , Cavallo , M , Carletto , S , Ostacoli , L , Zuffranieri , M , Picci , R L , Scavelli , F , Johnston , H , Furlan , P M , Bertolotto , A & Malucchi , S 2013 , ' Presence and significant determinants of cognitive impairment in a large sample of patients with Multiple Sclerosis ' , PLoS One , vol. 8 , no. 7 , e69820 . https://doi.org/10.1371/journal.pone.0069820en
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10023/5008
dc.descriptionThis work was supported by FISM - Fondazione Italiana Sclerosi Multipla (www.aism.it) - Cod. 2009/R/17.en
dc.description.abstractObjectives: To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS. Methods: 303 patients with MS and 279 healthy controls were administered the Brief Repeatable Battery of Neuropsychological tests (BRB-N); measures of pre-morbid verbal competence and neuropsychiatric measures were also administered. Results: Patients and healthy controls were matched for age, gender, education and pre-morbid verbal Intelligence Quotient. Patients presenting with cognitive impairment were 108/303 (35.6%). In the overall group of participants, the significant predictors of the most sensitive BRB-N scores were: presence of MS, age, education, and Vocabulary. The significant predictors when considering MS patients only were: course of MS, age, education, vocabulary, and depression. Using logistic regression analyses, significant determinants of the presence of cognitive impairment in relapsing-remitting MS patients were: duration of illness (OR = 1.053, 95% CI = 1.010-1.097, p = 0.015), Expanded Disability Status Scale score (OR = 1.247, 95% CI = 1.024-1.517, p = 0.028), and vocabulary (OR = 0.960, 95% CI = 0.936-0.984, p = 0.001), while in the smaller group of progressive MS patients these predictors did not play a significant role in determining the cognitive outcome. Conclusions: Our results corroborate the evidence about the presence and the nature of cognitive impairment in a large sample of patients with MS. Furthermore, our findings identify significant clinical and demographic determinants of cognitive impairment in a large sample of MS patients for the first time. Implications for further research and clinical practice were discussed.
dc.format.extent9
dc.format.extent170411
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.subjectBrief repeatable batteryen
dc.subjectScaleen
dc.subjectSpeeden
dc.subjectPopulationen
dc.subjectRelevanceen
dc.subjectDeficitsen
dc.subjectMemoryen
dc.subjectMSen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titlePresence and significant determinants of cognitive impairment in a large sample of patients with Multiple Sclerosisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.identifier.doi10.1371/journal.pone.0069820
dc.description.statusPeer revieweden


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