Medicine Theses: Recent submissions

Now showing items 136-140 of 143

    • The effects of leptomycin B on HPV-infected cells 

      Jolly, Carol E (University of St Andrews, 2008) - Thesis
      Cervical cancer is a major cause of death in women and is strongly associated with infection by human papillomavirus (HPV). Integration of HPV is thought to form a key step in the formation of cancer, and is thought to ...

    • A role for topoisomerase II alpha in chromosome damage in human cell lines 

      Terry, Samantha Y.A. (University of St Andrews, 2010-06) - Thesis
      Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations. Different frequencies of IR-induced ...

    • Cell cycle control and its modulation in HPV infected cells 

      Lyman, Rachel C. (University of St Andrews, 2010-07) - Thesis
      A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot ...

    • Development of a predictive DNA double strand break assay for the identification of individuals with high normal tissue radiosensitivity 

      Brown, Emma Jane Hay (University of St Andrews, 2008) - Thesis
      A genetically determined high level of intrinsic normal tissue radiosensitivity may account for the 5% of patients who experience unexpectedly severe normal tissue side effects following radiotherapy. The pre-treatment ...

    • The role of HLA-B27 in inflammatory arthritis 

      Lynch, Sarah Janice (University of St Andrews, 2009-11) - Thesis
      The MHC class I allele, HLA-B27, is strongly associated with a group of inflammatory arthritic conditions collectively known as spondyloarthropathies (SpA). Ankylosing spondylitis (AS) shows the strongest association with ...