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dc.contributor.authorChilds, Kay
dc.contributor.authorRandall, Richard
dc.contributor.authorGoodbourn, Stephen
dc.date.accessioned2014-07-03T10:31:01Z
dc.date.available2014-07-03T10:31:01Z
dc.date.issued2012-04
dc.identifier.citationChilds , K , Randall , R & Goodbourn , S 2012 , ' Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction ' Journal of Virology , vol. 86 , no. 7 , pp. 3411-3421 . DOI: 10.1128/JVI.06405-11en
dc.identifier.issn0022-538X
dc.identifier.otherPURE: 28557901
dc.identifier.otherPURE UUID: 6bd636f7-bea4-448c-9cf5-aff5c9093eeb
dc.identifier.otherWOS: 000301371500002
dc.identifier.otherScopus: 84861304915
dc.identifier.urihttp://hdl.handle.net/10023/4937
dc.identifier.urihttp://ukpmc.ac.uk/articles/PMC3302505en
dc.descriptionThis work was supported by the Wellcome Trust (grant AL087751/B)en
dc.description.abstractRIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD domains required for signaling. The V proteins of paramyxoviruses limit interferon induction by binding mda-5 and preventing its activation; however, they do not bind RIG-I and have not been considered inhibitors of RIG-I signaling. Here we uncover a novel mechanism of RIG-I inhibition in which the V protein of parainfluenzavirus type 5 (PIV5; formerly known as simian virus type 5 [SV5]) interacts with LGP2 and cooperatively inhibits induction by RIG-I ligands. A complex between RIG-I and LGP2 is observed in the presence of PIV5-V, and we propose that this complex is refractory to activation by RIG-I ligands. The V proteins from other paramyxoviruses also bind LGP2 and demonstrate LGP2-dependent inhibition of RIG-I signaling. This is significant, because it demonstrates a general mechanism for the targeting of the RIG-I pathway by paramyxoviruses.en
dc.format.extent11en
dc.language.isoeng
dc.relation.ispartofJournal of Virologyen
dc.rightsCopyright © 2012, American Society for Microbiology. All Rights Reserved. The authors have paid a fee to allow immediate free access to this article.en
dc.subjectQR355 Virologyen
dc.subject.lccQR355en
dc.titleParamyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon inductionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1128/JVI.06405-11
dc.description.statusPeer revieweden


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