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Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction
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dc.contributor.author | Childs, Kay | |
dc.contributor.author | Randall, Richard | |
dc.contributor.author | Goodbourn, Stephen | |
dc.date.accessioned | 2014-07-03T10:31:01Z | |
dc.date.available | 2014-07-03T10:31:01Z | |
dc.date.issued | 2012-04 | |
dc.identifier | 28557901 | |
dc.identifier | 6bd636f7-bea4-448c-9cf5-aff5c9093eeb | |
dc.identifier | 000301371500002 | |
dc.identifier | 84861304915 | |
dc.identifier.citation | Childs , K , Randall , R & Goodbourn , S 2012 , ' Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction ' , Journal of Virology , vol. 86 , no. 7 , pp. 3411-3421 . https://doi.org/10.1128/JVI.06405-11 | en |
dc.identifier.issn | 0022-538X | |
dc.identifier.other | ORCID: /0000-0002-9304-6678/work/60427023 | |
dc.identifier.uri | https://hdl.handle.net/10023/4937 | |
dc.description | This work was supported by the Wellcome Trust (grant AL087751/B) | en |
dc.description.abstract | RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD domains required for signaling. The V proteins of paramyxoviruses limit interferon induction by binding mda-5 and preventing its activation; however, they do not bind RIG-I and have not been considered inhibitors of RIG-I signaling. Here we uncover a novel mechanism of RIG-I inhibition in which the V protein of parainfluenzavirus type 5 (PIV5; formerly known as simian virus type 5 [SV5]) interacts with LGP2 and cooperatively inhibits induction by RIG-I ligands. A complex between RIG-I and LGP2 is observed in the presence of PIV5-V, and we propose that this complex is refractory to activation by RIG-I ligands. The V proteins from other paramyxoviruses also bind LGP2 and demonstrate LGP2-dependent inhibition of RIG-I signaling. This is significant, because it demonstrates a general mechanism for the targeting of the RIG-I pathway by paramyxoviruses. | |
dc.format.extent | 11 | |
dc.format.extent | 1646246 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Virology | en |
dc.subject | QR355 Virology | en |
dc.subject.lcc | QR355 | en |
dc.title | Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1128/JVI.06405-11 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | http://ukpmc.ac.uk/articles/PMC3302505 | en |
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