Medicine: Recent submissions
Now showing items 201-205 of 205
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Development of a predictive DNA double strand break assay for the identification of individuals with high normal tissue radiosensitivity
(University of St Andrews, 2008) - ThesisA genetically determined high level of intrinsic normal tissue radiosensitivity may account for the 5% of patients who experience unexpectedly severe normal tissue side effects following radiotherapy. The pre-treatment ... -
The role of HLA-B27 in inflammatory arthritis
(University of St Andrews, 2009-11) - ThesisThe MHC class I allele, HLA-B27, is strongly associated with a group of inflammatory arthritic conditions collectively known as spondyloarthropathies (SpA). Ankylosing spondylitis (AS) shows the strongest association with ... -
Development of an in vitro model for investigating the properties of human prostate epithelial cells and prostatic carcinoma cells
(University of St Andrews, 2009-06-26) - ThesisProstate cell lines were derived from two regions of prostate tissue from the same patient. The objective was to produce cell lines (as a useful in vitro model) from these two different regions which exhibit different ... -
Modification of the E1-pIX region of the adenovirus 5 genome for use in cancer gene therapy
(University of St Andrews, 2008) - ThesisCurrently the use of adenoviruses in cancer gene therapy is limited by efficient delivery of the virus into the tumour cells, detargeting of the virus from the liver, and the efficient spread of the virus within the ... -
Biomarkers of isoflavone intake : validity at high intakes
(University of St Andrews, 2007-06) - ThesisIsoflavones are biologically active plant chemicals (phytoestrogens) which are ordinarily present in human diets. There is considerable research interest in their potential to prevent or treat several chronic diseases. ...