Innovative solutions to novel drug development in mental health
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There are many new advances in neuroscience and mental health which should lead to a greater understanding of the neurobiological dysfunction in neuropsychiatric disorders and new developments for early, effective treatments. To do this, a biomarker approach combining genetic, neuroimaging, cognitive and other biological measures is needed. The aim of this article is to highlight novel approaches for pharmacological and non-pharmacological treatment development. This article suggests approaches that can be taken in the future including novel mechanisms with preliminary clinical validation to provide a toolbox for mechanistic studies and also examples of translation and back-translation. The review also emphasizes the need for clinician-scientists to be trained in a novel way in order to equip them with the conceptual and experimental techniques required, and emphasizes the need for private-public partnership and pre-competitive knowledge exchange. This should lead the way for important new holistic treatment developments to improve cognition, functional outcome and well-being of people with neuropsychiatric disorders.
Insel , T R , Voon , V , Nye , J S , Brown , V J , Altevogt , B M , Bullmore , E T , Goodwin , G M , Howard , R J , Kupfer , D J , Malloch , G , Marston , H M , Nutt , D J , Robbins , T W , Stahl , S M , Tricklebank , M D , Williams , J H & Sahakian , B J 2013 , ' Innovative solutions to novel drug development in mental health ' Neuroscience and Biobehavioral Reviews , vol 37 , no. 10 Part 1 , pp. 2438-2444 . DOI: 10.1016/j.neubiorev.2013.03.022
Neuroscience and Biobehavioral Reviews
© 2013 Elsevier Ltd. All rights reserved. Published as open access.
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