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dc.contributor.authorFatih, Farrah A.
dc.contributor.authorStaines, Henry M.
dc.contributor.authorSiner, Angela
dc.contributor.authorAhmed, Mohammed Atique
dc.contributor.authorWoon, Lu Chan
dc.contributor.authorPasini, Erica M.
dc.contributor.authorKocken, Clemens H. M.
dc.contributor.authorSingh, Balbir
dc.contributor.authorCox Singh, Janet
dc.contributor.authorKrishna, Sanjeev
dc.date.accessioned2014-05-06T14:31:00Z
dc.date.available2014-05-06T14:31:00Z
dc.date.issued2013-11-19
dc.identifier.citationFatih , F A , Staines , H M , Siner , A , Ahmed , M A , Woon , L C , Pasini , E M , Kocken , C H M , Singh , B , Cox Singh , J & Krishna , S 2013 , ' Susceptibility of human plasmodium knowlesi infections to anti-malarials ' , Malaria Journal , vol. 12 , 425 . https://doi.org/10.1186/1475-2875-12-425en
dc.identifier.issn1475-2875
dc.identifier.otherPURE: 116323332
dc.identifier.otherPURE UUID: df24b405-4907-4da4-bdab-50098177aeb9
dc.identifier.otherWOS: 000329105900001
dc.identifier.otherScopus: 84887716187
dc.identifier.otherORCID: /0000-0003-4878-5188/work/64034464
dc.identifier.urihttp://hdl.handle.net/10023/4712
dc.descriptionThis study was funded by the Medical Research Council (MRC) UK; Grant number G0801971 and the European Community’s Seventh Framework Programme (FP7/2007-2013), EVIMALAR network of Excellence under grant agreement N° 242095 and NANOMAL under grant agreement N° 304948en
dc.description.abstractBackground: Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure. Therefore, adequate response to available anti-malarial treatments is assumed. Methods: Here the ex vivo sensitivity of human P. knowlesi isolates in Malaysian Borneo were studied, using a WHO schizont maturation assay modified to accommodate the quotidian life cycle of this parasite. The in vitro sensitivities of P. knowlesi H strain adapted from a primate infection to in vitro culture (by measuring the production of Plasmodium lactate dehydrogenase) were also examined together with some assays using Plasmodium falciparum and Plasmodium vivax. Results: Plasmodium knowlesi is uniformly highly sensitive to artemisinins, variably and moderately sensitive to chloroquine, and less sensitive to mefloquine. Conclusions: Taken together with reports of clinical failures when P. knowlesi is treated with mefloquine, the data suggest that caution is required if using mefloquine in prevention or treatment of P. knowlesi infections, until further studies are undertaken.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofMalaria Journalen
dc.rights© 2013 Fatih et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectArtemisininen
dc.subjectArtemetheren
dc.subjectArtesunateen
dc.subjectDihydroartemisininen
dc.subjectDHAen
dc.subjectChloroquineen
dc.subjectMefloquineen
dc.subjectMalariaen
dc.subjectIn-vitroen
dc.subjectMefloquine resistanceen
dc.subjectVivax malariaen
dc.subjectPFMDR1 geneen
dc.subjectFalciparumen
dc.subjectMalaysiaen
dc.subjectSensitivityen
dc.subjectSabahen
dc.subjectErythrocytesen
dc.subjectAdaptationen
dc.subjectQR355 Virologyen
dc.subject.lccQR355en
dc.titleSusceptibility of human plasmodium knowlesi infections to anti-malarialsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Infection Groupen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1186/1475-2875-12-425
dc.description.statusPeer revieweden


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