Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorAdamson, Catherine S
dc.date.accessioned2014-05-01T12:01:01Z
dc.date.available2014-05-01T12:01:01Z
dc.date.issued2012
dc.identifier23262888
dc.identifier3d5a13b9-3a4a-48ef-b881-db5df30e111c
dc.identifier.citationAdamson , C S 2012 , ' Protease mediated maturation of HIV: Inhibitors of protease and the maturation process ' , Molecular Biology International , vol. 2012 Special Issue: Host-Pathogen Interactions , 604261 . https://doi.org/10.1155/2012/604261en
dc.identifier.urihttps://hdl.handle.net/10023/4684
dc.description.abstractProtease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol polyproteins into mature protein domains. Maturation triggers a second assembly event that generates a condensed conical capsid core. The capsid core organizes the viral RNA genome and viral proteins to facilitate viral replication in the next round of infection. The fundamental role of proteolytic maturation in the generation of mature infectious particles has made it an attractive target for therapeutic intervention. Development of small molecules that target the PR active site has been highly successful and nine protease inhibitors (PIs) have been approved for clinical use. This review provides an overview of their development and clinical use together with a discussion of problems associated with drug-resistance. The second-half of the review discusses a novel class of antiretroviral drug termed maturation inhibitors, which target cleavage sites in Gag not PR itself. The review focuses on bevirimat (BVM) the first-in-class maturation inhibitor; its mechanism of action and the implications of naturally occurring polymorphisms that confer reduced susceptibility to BVM in phase II clinical trials.
dc.format.extent13
dc.format.extent2540617
dc.language.isoeng
dc.relation.ispartofMolecular Biology Internationalen
dc.subjectHIVen
dc.subjectProteaseen
dc.subjectInhibitorsen
dc.subjectBevirimaten
dc.subjectQR355 Virologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQR355en
dc.titleProtease mediated maturation of HIV: Inhibitors of protease and the maturation processen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1155/2012/604261
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.hindawi.com/journals/mbi/2012/604261/en


This item appears in the following Collection(s)

Show simple item record