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dc.contributor.authorAdamson, Catherine S
dc.identifier.citationAdamson , C S 2012 , ' Protease mediated maturation of HIV: Inhibitors of protease and the maturation process ' , Molecular Biology International , vol. 2012 Special Issue: Host-Pathogen Interactions , 604261 .
dc.identifier.otherPURE: 23262888
dc.identifier.otherPURE UUID: 3d5a13b9-3a4a-48ef-b881-db5df30e111c
dc.description.abstractProtease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol polyproteins into mature protein domains. Maturation triggers a second assembly event that generates a condensed conical capsid core. The capsid core organizes the viral RNA genome and viral proteins to facilitate viral replication in the next round of infection. The fundamental role of proteolytic maturation in the generation of mature infectious particles has made it an attractive target for therapeutic intervention. Development of small molecules that target the PR active site has been highly successful and nine protease inhibitors (PIs) have been approved for clinical use. This review provides an overview of their development and clinical use together with a discussion of problems associated with drug-resistance. The second-half of the review discusses a novel class of antiretroviral drug termed maturation inhibitors, which target cleavage sites in Gag not PR itself. The review focuses on bevirimat (BVM) the first-in-class maturation inhibitor; its mechanism of action and the implications of naturally occurring polymorphisms that confer reduced susceptibility to BVM in phase II clinical trials.
dc.relation.ispartofMolecular Biology Internationalen
dc.rightsCopyright © 2012 Catherine S. Adamson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQR355 Virologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleProtease mediated maturation of HIV: Inhibitors of protease and the maturation processen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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