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dc.contributor.authorBarke, Joerg
dc.contributor.authorSeipke, Ryan F.
dc.contributor.authorGrueschow, Sabine
dc.contributor.authorHeavens, Darren
dc.contributor.authorDrou, Nizar
dc.contributor.authorBibb, Mervyn J.
dc.contributor.authorGoss, Rebecca J. M.
dc.contributor.authorYu, Douglas W.
dc.contributor.authorHutchings, Matthew I.
dc.date.accessioned2014-04-28T14:01:03Z
dc.date.available2014-04-28T14:01:03Z
dc.date.issued2010-08-26
dc.identifier.citationBarke , J , Seipke , R F , Grueschow , S , Heavens , D , Drou , N , Bibb , M J , Goss , R J M , Yu , D W & Hutchings , M I 2010 , ' A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus ' , BMC Biology , vol. 8 , 109 . https://doi.org/10.1186/1741-7007-8-109en
dc.identifier.issn1741-7007
dc.identifier.otherPURE: 50707772
dc.identifier.otherPURE UUID: 483f94d7-ad03-4024-ae23-dd62ef36fe2e
dc.identifier.otherWOS: 000283576100001
dc.identifier.otherScopus: 77956996758
dc.identifier.urihttp://hdl.handle.net/10023/4634
dc.descriptionThis work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081).en
dc.description.abstractBackground: Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing actinomycete bacteria. One hypothesis suggests that bacteria from the genus Pseudonocardia are the sole, co-evolved mutualists of attine ants and are transmitted vertically by the queens. A recent study identified a Pseudonocardia-produced antifungal, named dentigerumycin, associated with the lower attine Apterostigma dentigerum consistent with the idea that co-evolved Pseudonocardia make novel antibiotics. An alternative possibility is that attine ants sample actinomycete bacteria from the soil, selecting and maintaining those species that make useful antibiotics. Consistent with this idea, a Streptomyces species associated with the higher attine Acromyrmex octospinosus was recently shown to produce the well-known antifungal candicidin. Candicidin production is widespread in environmental isolates of Streptomyces, so this could either be an environmental contaminant or evidence of recruitment of useful actinomycetes from the environment. It should be noted that the two possibilities for actinomycete acquisition are not necessarily mutually exclusive. Results: In order to test these possibilities we isolated bacteria from a geographically distinct population of A. octospinosus and identified a candicidin-producing Streptomyces species, which suggests that they are common mutualists of attine ants, most probably recruited from the environment. We also identified a Pseudonocardia species in the same ant colony that produces an unusual polyene antifungal, providing evidence for co-evolution of Pseudonocardia with A. octospinosus. Conclusions: Our results show that a combination of co-evolution and environmental sampling results in the diversity of actinomycete symbionts and antibiotics associated with attine ants.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofBMC Biologyen
dc.rights© 2010 Barke et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectBacteriaen
dc.subjectGardenen
dc.subjectEscovopsisen
dc.subjectGene-clusteren
dc.subjectGrowing antsen
dc.subjectProtecten
dc.subjectBiosynthesisen
dc.subjectSymbiosisen
dc.subjectNystatinen
dc.subjectParasitesen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleA mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosusen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1186/1741-7007-8-109
dc.description.statusPeer revieweden


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