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dc.contributor.authorBailey, Nathan William
dc.contributor.authorHoskins, Jessica L.
dc.identifier.citationBailey , N W & Hoskins , J L 2014 , ' Detecting cryptic indirect genetic effects ' , Evolution , vol. 68 , no. 7 , pp. 1871-1882 .
dc.identifier.otherPURE: 104101183
dc.identifier.otherPURE UUID: 2a357046-387f-4d75-b7fc-19d6af5bccd6
dc.identifier.otherScopus: 84903547090
dc.identifier.otherWOS: 000339052000003
dc.identifier.otherORCID: /0000-0003-3531-7756/work/60888432
dc.descriptionResearch supported by NERC grants NE/G014906/1 & NE/I016937/1. APC paid through RCUK OA funds.en
dc.description.abstractIndirect genetic effects (IGEs) occur when genes expressed in one individual alter the phenotype of an interacting partner. IGEs can dramatically affect the expression and evolution of social traits. However, the interacting phenotype(s) through which they are transmitted are often unknown, or cryptic, and their detection would enhance our ability to accurately predict evolutionary change. To illustrate this challenge and possible solutions to it, we assayed male leg tapping behaviour using inbred lines of Drosophila melanogaster paired with a common focal male strain. The expression of tapping in focal males was dependent on the genotype of their interacting partner, but this strong IGE was cryptic. Using a multiple-regression approach, we identified male startle response as a candidate interacting phenotype: the longer it took interacting males to settle after being startled, the less focal males tapped them. A genome-wide association analysis identified approximately a dozen candidate protein-coding genes potentially underlying the IGE, of which the most significant was slowpoke. Our methodological framework provides information about candidate phenotypes and candidate SNPs that underpin a strong yet cryptic IGE. We discuss how this approach can facilitate the detection of cryptic IGEs contributing to unusual evolutionary dynamics in other study systems.
dc.rights© 2014 The Authors. Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution. This is an open access article under the terms of the Creative Commons Attribution License (, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectDrosophila melanogasteren
dc.subjectInteracting phenotypeen
dc.subjectInteraction coefficienten
dc.subjectPhenotype plasticityen
dc.subjectSocial evolutionen
dc.subjectSocial flexibilityen
dc.subjectQH426 Geneticsen
dc.titleDetecting cryptic indirect genetic effectsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.description.statusPeer revieweden

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