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dc.contributor.authorCastillo-Ramirez, Santiago
dc.contributor.authorHarris, Simon R.
dc.contributor.authorHolden, Matthew T. G.
dc.contributor.authorHe, Miao
dc.contributor.authorParkhill, Julian
dc.contributor.authorBentley, Stephen D.
dc.contributor.authorFeil, Edward J.
dc.date.accessioned2014-04-25T13:31:00Z
dc.date.available2014-04-25T13:31:00Z
dc.date.issued2011-07
dc.identifier91760570
dc.identifierc7c42839-aa29-48fa-99f8-85514c92f755
dc.identifier000293339300022
dc.identifier79960967240
dc.identifier.citationCastillo-Ramirez , S , Harris , S R , Holden , M T G , He , M , Parkhill , J , Bentley , S D & Feil , E J 2011 , ' The impact of recombination on dN/dS within recently emerged bacterial clones ' , PLoS Pathogens , vol. 7 , no. 7 , e1002129 . https://doi.org/10.1371/journal.ppat.1002129en
dc.identifier.issn1553-7374
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196431
dc.identifier.urihttps://hdl.handle.net/10023/4614
dc.descriptionSCR and EF are funded by the TROCAR consortium (EU FP7-HEALTH #223031). http://www.trocarproject.eu/ The Sanger Institute is core funded by the Wellcome Trust.en
dc.description.abstractThe development of next-generation sequencing platforms is set to reveal an unprecedented level of detail on short-term molecular evolutionary processes in bacteria. Here we re-analyse genome-wide single nucleotide polymorphism (SNP) datasets for recently emerged clones of methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile. We note a highly significant enrichment of synonymous SNPs in those genes which have been affected by recombination, i.e. those genes on mobile elements designated "non-core" (in the case of S. aureus), or those core genes which have been affected by homologous replacements (S. aureus and C. difficile). This observation suggests that the previously documented decrease in dN/dS over time in bacteria applies not only to genomes of differing levels of divergence overall, but also to horizontally acquired genes of differing levels of divergence within a single genome. We also consider the role of increased drift acting on recently emerged, highly specialised clones, and the impact of recombination on selection at linked sites. This work has implications for a wide range of genomic analyses.
dc.format.extent13
dc.format.extent647144
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.subjectResistant Staphylococcus-Aureusen
dc.subjectMethicillin-resistanten
dc.subjectDrosophilia-Melanogasteren
dc.subjectEscherichia-colien
dc.subjectComplete genomesen
dc.subjectDeleterious mutationen
dc.subjectMycobacterium-bovisen
dc.subjectAsian countriesen
dc.subjectHigh-throughputen
dc.subjectEvolutionen
dc.titleThe impact of recombination on dN/dS within recently emerged bacterial clonesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1371/journal.ppat.1002129
dc.description.statusPeer revieweden


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