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dc.contributor.authorZhong, Weihao
dc.contributor.authorMcClure, Colin D.
dc.contributor.authorEvans, Cara R.
dc.contributor.authorMlynski, David T.
dc.contributor.authorImmonen, Elina
dc.contributor.authorRitchie, Michael Gordon
dc.contributor.authorPriest, Nicholas K.
dc.date.accessioned2014-02-26T11:01:02Z
dc.date.available2014-02-26T11:01:02Z
dc.date.issued2013-12
dc.identifier.citationZhong , W , McClure , C D , Evans , C R , Mlynski , D T , Immonen , E , Ritchie , M G & Priest , N K 2013 , ' Immune anticipation of mating in Drosophila : Turandot M promotes immunity against sexually transmitted fungal infections ' , Proceedings of the Royal Society B: Biological Sciences , vol. 280 , no. 1773 , 20132018 . https://doi.org/10.1098/rspb.2013.2018en
dc.identifier.issn0962-8452
dc.identifier.otherPURE: 99623087
dc.identifier.otherPURE UUID: 41323103-85ff-4c61-a8ec-192968f3e691
dc.identifier.otherScopus: 84886997693
dc.identifier.otherORCID: /0000-0001-7913-8675/work/46761151
dc.identifier.urihttp://hdl.handle.net/10023/4468
dc.description.abstractAlthough it is well known that mating increases the risk of infection, we do not know how females mitigate the fitness costs of sexually transmitted infections (STIs). It has recently been shown that female fruitflies, Drosophila melanogaster, specifically upregulate two members of the Turandot family of immune and stress response genes, Turandot M and Turandot C (TotM and TotC), when they hear male courtship song. Here, we use the Gal4/UAS RNAi gene knockdown system to test whether the expression of these genes provides fitness benefits for females infected with the entomopathogenic fungus, Metarhizium robertsii under sexual transmission. As a control, we also examined the immunity conferred by Dorsal-related immunity factor (Dif), a central component of the Toll signalling pathway thought to provide immunity against fungal infections. We show that TotM, but not TotC or Dif, provides survival benefits to females following STIs, but not after direct topical infections. We also show that though the expression of TotM provides fecundity benefits for healthy females, it comes at a cost to their survival, which helps to explain why TotM is not constitutively expressed. Together, these results show that the anticipatory expression of TotM promotes specific immunity against fungal STIs and suggest that immune anticipation is more common than currently appreciated.
dc.language.isoeng
dc.relation.ispartofProceedings of the Royal Society B: Biological Sciencesen
dc.rights© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.en
dc.subjectImmune anticipationen
dc.subjectSexually transmitted infectionsen
dc.subjectEcological immunologyen
dc.subjectDrosophila melanogasteren
dc.subjectMetarhizium robertsiien
dc.subjectInnate imunityen
dc.titleImmune anticipation of mating in Drosophila : Turandot M promotes immunity against sexually transmitted fungal infectionsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Centre for Biological Diversityen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1098/rspb.2013.2018
dc.description.statusPeer revieweden


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