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dc.contributor.authorScerri, Thomas S.
dc.contributor.authorBrandler, William M.
dc.contributor.authorParacchini, Silvia
dc.contributor.authorMorris, Andrew P.
dc.contributor.authorRing, Susan M.
dc.contributor.authorRichardson, Alex J.
dc.contributor.authorTalcott, Joel B.
dc.contributor.authorStein, John
dc.contributor.authorMonaco, Anthony P.
dc.date.accessioned2013-12-16T10:01:00Z
dc.date.available2013-12-16T10:01:00Z
dc.date.issued2011-02
dc.identifier.citationScerri , T S , Brandler , W M , Paracchini , S , Morris , A P , Ring , S M , Richardson , A J , Talcott , J B , Stein , J & Monaco , A P 2011 , ' PCSK6 is associated with handedness in individuals with dyslexia ' Human Molecular Genetics , vol. 20 , no. 3 , pp. 608-614 . https://doi.org/10.1093/hmg/ddq475en
dc.identifier.issn0964-6906
dc.identifier.otherPURE: 13909696
dc.identifier.otherPURE UUID: 0f8751c5-c4b3-43a3-8adf-62a43ccf83ae
dc.identifier.otherWOS: 000286006300017
dc.identifier.otherScopus: 78651077537
dc.identifier.otherORCID: /0000-0001-9934-8602/work/60428071
dc.identifier.urihttp://hdl.handle.net/10023/4298
dc.description.abstractApproximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associated marker, rs11855415 (P = 4.7 x 10(-7)), is located within PCSK6. Two independent cohorts with RD show the same trend, with the minor allele conferring greater relative right-hand skill. Meta-analysis of all three RD samples is genome-wide significant (n = 744, P = 2.0 x 10(-8)). Conversely, in the general population (n = 2666), we observe a trend towards reduced laterality of hand skill for the minor allele (P = 0.0020). These results provide molecular evidence that cerebral asymmetry and dyslexia are linked. Furthermore, PCSK6 is a protease that cleaves the left-right axis determining protein NODAL. Functional studies of PCSK6 promise insights into mechanisms underlying cerebral lateralization and dyslexia.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofHuman Molecular Geneticsen
dc.rights© The Author 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQuantitative-trait locusen
dc.subjectGenome-wide associationen
dc.subjectRelative hand skillen
dc.subjectDevelopmental dyslexiaen
dc.subjectSusceptibility geneen
dc.subjectREading-disabilityen
dc.subjectLinkage analysisen
dc.subjectChromosome 6Pen
dc.subjectUnited Statesen
dc.subjectLanguageen
dc.subjectQH426 Geneticsen
dc.subject.lccQH426en
dc.titlePCSK6 is associated with handedness in individuals with dyslexiaen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1093/hmg/ddq475
dc.description.statusPeer revieweden


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