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PCSK6 is associated with handedness in individuals with dyslexia
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dc.contributor.author | Scerri, Thomas S. | |
dc.contributor.author | Brandler, William M. | |
dc.contributor.author | Paracchini, Silvia | |
dc.contributor.author | Morris, Andrew P. | |
dc.contributor.author | Ring, Susan M. | |
dc.contributor.author | Richardson, Alex J. | |
dc.contributor.author | Talcott, Joel B. | |
dc.contributor.author | Stein, John | |
dc.contributor.author | Monaco, Anthony P. | |
dc.date.accessioned | 2013-12-16T10:01:00Z | |
dc.date.available | 2013-12-16T10:01:00Z | |
dc.date.issued | 2011-02 | |
dc.identifier.citation | Scerri , T S , Brandler , W M , Paracchini , S , Morris , A P , Ring , S M , Richardson , A J , Talcott , J B , Stein , J & Monaco , A P 2011 , ' PCSK6 is associated with handedness in individuals with dyslexia ' , Human Molecular Genetics , vol. 20 , no. 3 , pp. 608-614 . https://doi.org/10.1093/hmg/ddq475 | en |
dc.identifier.issn | 0964-6906 | |
dc.identifier.other | PURE: 13909696 | |
dc.identifier.other | PURE UUID: 0f8751c5-c4b3-43a3-8adf-62a43ccf83ae | |
dc.identifier.other | WOS: 000286006300017 | |
dc.identifier.other | Scopus: 78651077537 | |
dc.identifier.other | ORCID: /0000-0001-9934-8602/work/60428071 | |
dc.identifier.uri | https://hdl.handle.net/10023/4298 | |
dc.description.abstract | Approximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associated marker, rs11855415 (P = 4.7 x 10(-7)), is located within PCSK6. Two independent cohorts with RD show the same trend, with the minor allele conferring greater relative right-hand skill. Meta-analysis of all three RD samples is genome-wide significant (n = 744, P = 2.0 x 10(-8)). Conversely, in the general population (n = 2666), we observe a trend towards reduced laterality of hand skill for the minor allele (P = 0.0020). These results provide molecular evidence that cerebral asymmetry and dyslexia are linked. Furthermore, PCSK6 is a protease that cleaves the left-right axis determining protein NODAL. Functional studies of PCSK6 promise insights into mechanisms underlying cerebral lateralization and dyslexia. | |
dc.format.extent | 7 | |
dc.language.iso | eng | |
dc.relation.ispartof | Human Molecular Genetics | en |
dc.rights | © The Author 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.subject | Quantitative-trait locus | en |
dc.subject | Genome-wide association | en |
dc.subject | Relative hand skill | en |
dc.subject | Developmental dyslexia | en |
dc.subject | Susceptibility gene | en |
dc.subject | REading-disability | en |
dc.subject | Linkage analysis | en |
dc.subject | Chromosome 6P | en |
dc.subject | United States | en |
dc.subject | Language | en |
dc.subject | QH426 Genetics | en |
dc.subject.lcc | QH426 | en |
dc.title | PCSK6 is associated with handedness in individuals with dyslexia | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1093/hmg/ddq475 | |
dc.description.status | Peer reviewed | en |
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