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dc.contributor.authorUbeda, Francisco
dc.contributor.authorOhtsuki, Hisashi
dc.contributor.authorGardner, Andy
dc.date.accessioned2013-12-10T12:01:02Z
dc.date.available2013-12-10T12:01:02Z
dc.date.issued2014-02
dc.identifier.citationUbeda , F , Ohtsuki , H & Gardner , A 2014 , ' Ecology drives intragenomic conflict over menopause ' Ecology Letters , vol. 17 , no. 2 , pp. 165-174 . DOI: 10.1111/ele.12208en
dc.identifier.issn1461-023X
dc.identifier.otherPURE: 84192639
dc.identifier.otherPURE UUID: f12ed293-3172-40c0-bd23-0bf7b53992c3
dc.identifier.otherWOS: 000329139800005
dc.identifier.otherWOS: 000329139800005
dc.identifier.otherScopus: 84891485993
dc.identifier.urihttp://hdl.handle.net/10023/4282
dc.description.abstractMenopause is the transition from reproductive to non-reproductive life well before natural death. Rather than involving a smooth, rapid change, it is normally preceded by a long period of erratic hormonal fluctuation that is accompanied by a plethora of unpleasant symptoms. Here, we (1) suggest that this turbulent period owes to conflict, between a woman's maternally inherited (MI) and paternally inherited (PI) genes, over the trade-off between reproduction and communal care; (2) perform a theoretical analysis to show that this conflict is resolved either through silencing or fluctuating expression of one of the genes; (3) highlight which of the symptoms preceding menopause may result from antagonistic co-evolution of MI and PI genes; (4) argue that ecological differences between ancestral human populations may explain the variability in menopause among different ethnic groups; (5) discuss how these insights may be used to inform family planning and cancer risk assessment based on a woman's ancestral background.en
dc.format.extent10en
dc.language.isoeng
dc.relation.ispartofEcology Lettersen
dc.rights© 2013 The Authors. Ecology Letters published by John Wiley & Sons Ltd and CNRS. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.subjectCanceren
dc.subjectCooperationen
dc.subjectDemographyen
dc.subjectFertilityen
dc.subjectGame theoryen
dc.subjectGenomic imprintingen
dc.subjectHumansen
dc.subjectHunter gatherersen
dc.subjectKin selectionen
dc.subjectMigrationen
dc.subjectQH426 Geneticsen
dc.subject.lccQH426en
dc.titleEcology drives intragenomic conflict over menopauseen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.identifier.doihttps://doi.org/10.1111/ele.12208
dc.description.statusPeer revieweden


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