The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm
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The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
Xiao , H , Killip , M J , Staeheli , P , Randall , R E & Jackson , D 2013 , ' The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm ' Journal of Virology , vol. 87 , no. 23 , pp. 13053-13058 . DOI: 10.1128/JVI.02220-13
Journal of Virology
Copyright © 2013 Xiao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
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