The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm
Abstract
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
Citation
Xiao , H , Killip , M J , Staeheli , P , Randall , R E & Jackson , D 2013 , ' The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm ' , Journal of Virology , vol. 87 , no. 23 , pp. 13053-13058 . https://doi.org/10.1128/JVI.02220-13
Publication
Journal of Virology
Status
Peer reviewed
ISSN
0022-538XType
Journal article
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