The first organocatalytic carbonyl-ene reaction : isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas

Clarke, Matthew L.; Jones, Charlotte E. S.; France, Marcia B.

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dc.contributor.author	Clarke, Matthew L.
dc.contributor.author	Jones, Charlotte E. S.
dc.contributor.author	France, Marcia B.
dc.date.accessioned	2013-12-05T11:31:01Z
dc.date.available	2013-12-05T11:31:01Z
dc.date.issued	2007-09-14
dc.identifier.citation	Clarke , M L , Jones , C E S & France , M B 2007 , ' The first organocatalytic carbonyl-ene reaction : isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas ' , Beilstein Journal of Organic Chemistry , vol. 3 , 24 . https://doi.org/10.1186/1860-5397-3-24	en
dc.identifier.other	PURE: 623855
dc.identifier.other	PURE UUID: 3f93b7d3-d54a-4f89-97ed-64b7fcb2e02a
dc.identifier.other	WOS: 000252525900001
dc.identifier.other	Scopus: 38149081322
dc.identifier.other	ORCID: /0000-0002-2444-1244/work/59464630
dc.identifier.uri	http://hdl.handle.net/10023/4267
dc.description.abstract	Intramolecular carbonyl ene reactions of highly activated enophiles can be catalysed by H-bonding thio-ureas to give tertiary alcohols in high yields without extensive isomerisation side products. An asymmetric variant of this reaction was realised using a chiral thiourea but was limited by low enantioselectivity (up to 33% e. e.) and low turnover frequencies.
dc.format.extent	4
dc.language.iso	eng
dc.relation.ispartof	Beilstein Journal of Organic Chemistry	en
dc.rights	© 2007 Clarke et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)	en
dc.subject	ASYMMETRIC CATALYSIS	en
dc.subject	COMPLEXES	en
dc.subject	ACIDS	en
dc.subject	QD Chemistry	en
dc.subject.lcc	QD	en
dc.title	The first organocatalytic carbonyl-ene reaction : isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas	en
dc.type	Journal article	en
dc.description.version	Publisher PDF	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.contributor.institution	University of St Andrews. EaSTCHEM	en
dc.identifier.doi	https://doi.org/10.1186/1860-5397-3-24
dc.description.status	Peer reviewed	en
dc.identifier.url	http://www.scopus.com/inward/record.url?scp=38149081322&partnerID=8YFLogxK	en

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