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dc.contributor.authorFerrier, David Ellard Keith
dc.contributor.authorThe International Aphid Genomics Consortium
dc.date.accessioned2013-12-04T12:01:03Z
dc.date.available2013-12-04T12:01:03Z
dc.date.issued2010-02
dc.identifier.citationFerrier , D E K & The International Aphid Genomics Consortium 2010 , ' Genome sequence of the pea aphid Acyrthosiphon pisum ' , PLoS Biology , vol. 8 , no. 2 , e1000313 . https://doi.org/doi:10.1371/journal.pbio.1000313en
dc.identifier.issn1545-7885
dc.identifier.otherPURE: 2384396
dc.identifier.otherPURE UUID: adaa61ef-ccda-47c1-b88b-f8083f8807af
dc.identifier.otherScopus: 77649141259
dc.identifier.otherORCID: /0000-0003-3247-6233/work/36423834
dc.identifier.urihttp://hdl.handle.net/10023/4256
dc.description.abstractAphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.
dc.language.isoeng
dc.relation.ispartofPLoS Biologyen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.en
dc.subjectPea aphiden
dc.subjectGenome sequenceen
dc.titleGenome sequence of the pea aphid Acyrthosiphon pisumen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.identifier.doihttps://doi.org/doi:10.1371/journal.pbio.1000313
dc.description.statusPeer revieweden


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