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The coevolution of virulence : tolerance in perspective

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e1001006.pdf (146.7Kb)
Date
09/2010
Author
Little, Tom J.
Shuker, David M.
Colegrave, Nick
Day, Troy
Graham, Andrea L.
Funder
NERC
Grant ID
NE/D009979/2
Keywords
HOST-PARASITE INTERACTIONS
GENETIC-VARIATION
EVOLUTION
RESISTANCE
SELECTION
HYPOTHESIS
IMMUNOLOGY
DYNAMICS
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Abstract
Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors. It is clear, for example, that the evolution of pollination strategies can only be understood with knowledge of both the pollinator and the pollinated. Studies of the evolution of virulence, the reduction in host fitness due to infection, have nonetheless tended to focus on parasite evolution. Host-centric approaches have also been proposed-for example, under the rubric of "tolerance", the ability of hosts to minimize virulence without necessarily minimizing parasite density. Within the tolerance framework, however, there is room for more comprehensive measures of host fitness traits, and for fuller consideration of the consequences of coevolution. For example, the evolution of tolerance can result in changed selection on parasite populations, which should provoke parasite evolution despite the fact that tolerance is not directly antagonistic to parasite fitness. As a result, consideration of the potential for parasite counter-adaptation to host tolerance-whether evolved or medially manipulated-is essential to the emergence of a cohesive theory of biotic partnerships and robust disease control strategies.
Citation
Little , T J , Shuker , D M , Colegrave , N , Day , T & Graham , A L 2010 , ' The coevolution of virulence : tolerance in perspective ' , PLoS Pathogens , vol. 6 , no. 9 , e1001006 . https://doi.org/10.1371/journal.ppat.1001006
Publication
PLoS Pathogens
Status
Peer reviewed
DOI
https://doi.org/10.1371/journal.ppat.1001006
ISSN
1553-7374
Type
Journal item
Rights
© 2010 Little et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/4237

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