Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand
Abstract
Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.
Citation
Fuentes García , J A , Carpenter , I , Kann , N & Clarke , M 2013 , ' Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand ' , Chemical Communications , vol. 49 , no. 87 , pp. 10245-10247 . https://doi.org/10.1039/C3CC45545A
Publication
Chemical Communications
Status
Peer reviewed
ISSN
1359-7345Type
Journal article
Rights
Copyright 2013, the Authors. This is an Open Access article licensed under a Creative Commons Attribution 3.0 Unported Licence.
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