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dc.contributor.authorKelsey, Tom
dc.contributor.authorWright, Phoebe
dc.contributor.authorNelson, Scott
dc.contributor.authorAnderson, Richard
dc.contributor.authorWallace, Hamish
dc.date.accessioned2013-09-17T11:01:02Z
dc.date.available2013-09-17T11:01:02Z
dc.date.issued2011-07-15
dc.identifier.citationKelsey , T , Wright , P , Nelson , S , Anderson , R & Wallace , H 2011 , ' A validated model of serum anti-Müllerian hormone from conception to menopause ' , PLoS ONE , vol. 6 , no. 7 , e22024 . https://doi.org/10.1371/journal.pone.0022024en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 12009518
dc.identifier.otherPURE UUID: 73563ba0-6694-46a4-96a0-ddfabdcc4939
dc.identifier.otherScopus: 79960293852
dc.identifier.otherWOS: 000292811700015
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201560
dc.identifier.urihttp://hdl.handle.net/10023/4056
dc.description.abstractBackground Anti-Müllerian hormone (AMH) is a product of growing ovarian follicles. The concentration of AMH in blood may also reflect the non-growing follicle (NGF) population, i.e. the ovarian reserve, and be of value in predicting reproductive lifespan. A full description of AMH production up to the menopause has not been previously reported. Methodology/Principal Findings By searching the published literature for AMH concentrations in healthy pre-menopausal females, and using our own data (combined ) we have generated and robustly validated the first model of AMH concentration from conception to menopause. This model shows that 34% of the variation in AMH is due to age alone. We have shown that AMH peaks at age 24.5 years, followed by a decline to the menopause. We have also shown that there is a neonatal peak and a potential pre-pubertal peak. Our model allows us to generate normative data at all ages. Conclusions/Significance These data highlight key inflection points in ovarian follicle dynamics. This first validated model of circulating AMH in healthy females describes a transition period in early adulthood, after which AMH reflects the progressive loss of the NGF pool. The existence of a neonatal increase in gonadal activity is confirmed for females. An improved understanding of the relationship between circulating AMH and age will lead to more accurate assessment of ovarian reserve for the individual woman.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofPLoS ONEen
dc.rights© 2011 Kelsey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectQP Physiologyen
dc.subject.lccQPen
dc.titleA validated model of serum anti-Müllerian hormone from conception to menopauseen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Interdisciplinary Research in Computational Algebraen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0022024
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022024en


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