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dc.contributor.authorTreweek, Shaun
dc.contributor.authorLockhart, Pauline
dc.contributor.authorPitkethly, Marie
dc.contributor.authorCook, Jonathan A.
dc.contributor.authorKjeldstrom, Monica
dc.contributor.authorJohansen, Marit
dc.contributor.authorTaskila, Taina K.
dc.contributor.authorSullivan, Frank M.
dc.contributor.authorWilson, Sue
dc.contributor.authorJackson, Catherine
dc.contributor.authorJones, Ritu
dc.contributor.authorMitchell, Elizabeth D.
dc.date.accessioned2013-08-06T16:01:02Z
dc.date.available2013-08-06T16:01:02Z
dc.date.issued2013-02-07
dc.identifier46201081
dc.identifier25f46ad6-fdb8-4d54-8fb1-2b7eb2eb7e93
dc.identifier000315087200044
dc.identifier23396504
dc.identifier84875022120
dc.identifier.citationTreweek , S , Lockhart , P , Pitkethly , M , Cook , J A , Kjeldstrom , M , Johansen , M , Taskila , T K , Sullivan , F M , Wilson , S , Jackson , C , Jones , R & Mitchell , E D 2013 , ' Methods to improve recruitment to randomised controlled trials : Cochrane systematic review and meta-analysis ' , BMJ Open , vol. 3 , no. 2 , e002360 . https://doi.org/10.1136/bmjopen-2012-002360en
dc.identifier.issn2044-6055
dc.identifier.urihttps://hdl.handle.net/10023/3936
dc.descriptionThis review is an abridged version of a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI: 10.1002/14651858.MR000013.pub5en
dc.description.abstractObjective: To identify interventions designed to improve recruitment to randomised controlled trials, and to quantify their effect on trial participation. Design: Systematic review. Data sources: The Cochrane Methodology Review Group Specialised Register in the Cochrane Library, MEDLINE, EMBASE, ERIC, Science Citation Index, Social Sciences Citation Index, C2-SPECTR, the National Research Register and PubMed. Most searches were undertaken up to 2010; no language restrictions were applied. Study selection: Randomised and quasi-randomised controlled trials, including those recruiting to hypothetical studies. Studies on retention strategies, examining ways to increase questionnaire response or evaluating the use of incentives for clinicians were excluded. The study population included any potential trial participant (eg, patient, clinician and member of the public), or individual or group of individuals responsible for trial recruitment (eg, clinicians, researchers and recruitment sites). Two authors independently screened identified studies for eligibility. Results: 45 trials with over 43 000 participants were included. Some interventions were effective in increasing recruitment: telephone reminders to non-respondents (risk ratio (RR) 1.66, 95% CI 1.03 to 2.46; two studies, 1058 participants), use of opt-out rather than opt-in procedures for contacting potential participants (RR 1.39, 95% CI 1.06 to 1.84; one study, 152 participants) and open designs where participants know which treatment they are receiving in the trial (RR 1.22, 95% CI 1.09 to 1.36; two studies, 4833 participants). However, the effect of many other strategies is less clear, including the use of video to provide trial information and interventions aimed at recruiters. Conclusions: There are promising strategies for increasing recruitment to trials, but some methods, such as open-trial designs and opt-out strategies, must be considered carefully as their use may also present methodological or ethical challenges. Questions remain as to the applicability of results originating from hypothetical trials, including those relating to the use of monetary incentives, and there is a clear knowledge gap with regard to effective strategies aimed at recruiters.
dc.format.extent24
dc.format.extent1136564
dc.language.isoeng
dc.relation.ispartofBMJ Openen
dc.subjectRandomised controlled trialsen
dc.subjectRecruitmenten
dc.subjectRetention strategiesen
dc.subjectQuestionnaire responseen
dc.subjectR Medicine (General)en
dc.subject.lccR1en
dc.titleMethods to improve recruitment to randomised controlled trials : Cochrane systematic review and meta-analysisen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doi10.1136/bmjopen-2012-002360
dc.description.statusPeer revieweden


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