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dc.contributor.authorSloan, Derek J.
dc.contributor.authorVan Oosterhout, Joep J.
dc.contributor.authorMalisita, Ken
dc.contributor.authorPhiri, Eddie M.
dc.contributor.authorLalloo, David G.
dc.contributor.authorO'Hare, Bernadette
dc.contributor.authorMacPherson, Peter
dc.date.accessioned2013-05-28T15:31:00Z
dc.date.available2013-05-28T15:31:00Z
dc.date.issued2013-05-21
dc.identifier53889312
dc.identifierd656692b-9e5d-4cc9-9af5-8569eac53eb1
dc.identifier84877904981
dc.identifier84877904981
dc.identifier23687946
dc.identifier.citationSloan , D J , Van Oosterhout , J J , Malisita , K , Phiri , E M , Lalloo , D G , O'Hare , B & MacPherson , P 2013 , ' Evidence of improving antiretroviral therapy treatment delays : an analysis of eight years of programmatic outcomes in Blantyre, Malawi ' , BMC Public Health , vol. 13 , 490 . https://doi.org/10.1186/1471-2458-13-490en
dc.identifier.issn1471-2458
dc.identifier.otherORCID: /0000-0003-1730-7941/work/27345673
dc.identifier.otherORCID: /0000-0002-7888-5449/work/60631046
dc.identifier.urihttps://hdl.handle.net/10023/3562
dc.description.abstractAbstractBackground: Impressive achievements have been made towards achieving universal coverage of antiretroviral therapy (ART) in sub-Saharan Africa. However, the effects of rapid ART scale-up on delays between HIV diagnosisand treatment initiation have not been well described.Methods: A retrospective cohort study covering eight years of ART initiators (2004–2011) was conducted at Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi. The time between most recent positive HIV test and ARTinitiation was calculated and temporal trends in delay to initiation were described. Factors associated with time to initiation were investigated using multivariate regression analysis.Results: From 2004–2011, there were 15,949 ART initiations at QECH (56% female; 8% children [0–10 years] and 5% adolescents [10–20 years]). Male initiators were likely to have more advanced HIV infection at initiation than female initiators (70% vs. 64% in WHO stage 3 or 4). Over the eight years studied, there were declines in treatment delay, with 2011 having the shortest delay at 36.5 days. On multivariate analysis CD4 count <50 cells/μl (adjusted geometric mean ratio [aGMR]: aGMR: 0.53, bias-corrected accelerated [BCA] 95% CI: 0.42-0.68) was associated with shorter ART treatment delay. Women (aGMR: 1.12, BCA 95% CI: 1.03-1.22) and patients diagnosed with HIV at another facility outside QECH (aGMR: 1.61, BCA 95% CI: 1.47-1.77) had significantly longer treatment delay.Conclusions: Continued improvements in treatment delays provide evidence that universal access to ART can be achieved using the public health approach adopted by Malawi However, the longer delays for women and patients diagnosed at outlying sites emphasises the need for targeted interventions to support equitable access for these groups.
dc.format.extent7
dc.format.extent427083
dc.language.isoeng
dc.relation.ispartofBMC Public Healthen
dc.subjectAfricaen
dc.subjectAntiretroviral therapyen
dc.subjectHIVen
dc.subjectHIV testing and counsellingen
dc.subjectLinkage to careen
dc.subjectProgrammatic researchen
dc.subjectQR355 Virologyen
dc.subjectRA Public aspects of medicineen
dc.subjectPublic Health, Environmental and Occupational Healthen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQR355en
dc.subject.lccRAen
dc.titleEvidence of improving antiretroviral therapy treatment delays : an analysis of eight years of programmatic outcomes in Blantyre, Malawien
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Global Health Implementation Groupen
dc.identifier.doi10.1186/1471-2458-13-490
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.biomedcentral.com/1471-2458/13/490en


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