Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease
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Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.
Giardini , M E , Guizzetti , G G , Bavera , M , Lago , P , Corti , A , Falcone , C & Pastore , F 2001 , Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease . in W S Grundfest , D A Benaron & T VoDinh (eds) , Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III . SPIE Proceedings , vol. 4254 , SPIE-The International Society for Optical Engineering , Bellingham , pp. 1-6 , 3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems , SAN JOSE , 21-22 January . DOI: 10.1117/12.427938conference
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Mario E. Giardini, Giovanni G. Guizzetti, Matteo Bavera, Paolo Lago , Mario Corti, Colomba Falcone and Federico Pastore, "Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease" Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, Tuan Vo-Dinh, Warren S. Grundfest, David A. Benaron, Editors, Proc. SPIE 4254, 1 (2001). Copyright 2001 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.427938
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