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dc.contributor.authorMoleirinho, Susan
dc.contributor.authorPatrick, Calum
dc.contributor.authorTilston-Lunel, Andrew Martin
dc.contributor.authorHigginson, JR
dc.contributor.authorAngus, Liselotte
dc.contributor.authorAntkowiak, Maciej
dc.contributor.authorBarnett, Susan
dc.contributor.authorPrystowsky, Michael
dc.contributor.authorReynolds, Paul Andrew
dc.contributor.authorGunn-Moore, Frank J
dc.date.accessioned2013-04-10T13:31:04Z
dc.date.available2013-04-10T13:31:04Z
dc.date.issued2013-04-08
dc.identifier.citationMoleirinho , S , Patrick , C , Tilston-Lunel , A M , Higginson , JR , Angus , L , Antkowiak , M , Barnett , S , Prystowsky , M , Reynolds , P A & Gunn-Moore , F J 2013 , ' Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts ' , PLoS ONE , vol. 8 , no. 4 , e60028 . https://doi.org/10.1371/journal.pone.0060028en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 46464562
dc.identifier.otherPURE UUID: 7b738728-0d84-4f70-8ae9-86323dd2b231
dc.identifier.otherScopus: 84876005254
dc.identifier.otherORCID: /0000-0001-8738-1245/work/34034579
dc.identifier.otherORCID: /0000-0003-3422-3387/work/34730438
dc.identifier.urihttp://hdl.handle.net/10023/3474
dc.description.abstractWillin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator YAP through Ser127 phosphorylation. This in turn suppresses the expression of genes involved in cell growth, proliferation and cancer development ensuring the control of organ size, cell contact inhibition and apoptosis. Here we show that in the mammalian sciatic nerve, Willin is predominantly expressed in fibroblasts and that Willin expression activates the Hippo signaling cascade and induces YAP translocation from the nucleus to the cytoplasm. In addition within these cells, although it inhibits cellular proliferation, Willin expression induces a quicker directional migration towards scratch closure and an increased expression of factors linked to nerve regeneration. These results show that Willin modulates sciatic nerve fibroblast activity indicating that Willin may have a potential role in the regeneration of the peripheral nervous system.
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofPLoS ONEen
dc.rights© 2013 Moleirinho et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectQP Physiologyen
dc.subject.lccQPen
dc.titleWillin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblastsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0060028
dc.description.statusPeer revieweden


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