Show simple item record

Files in this item


Item metadata

dc.contributor.authorMoult, Peter Robert
dc.contributor.authorCottrell, Glen Alfred
dc.contributor.authorLi, Wenchang
dc.identifier.citationMoult , P R , Cottrell , G A & Li , W 2013 , ' Fast silencing reveals a lost role for reciprocal inhibition in locomotion ' , Neuron , vol. 77 , no. 1 , pp. 129-140 .
dc.identifier.otherPURE: 42943976
dc.identifier.otherPURE UUID: 1a13399b-f58a-4958-8212-53e068b72511
dc.identifier.otherScopus: 84872180961
dc.identifier.otherWOS: 000313404600013
dc.identifier.otherORCID: /0000-0002-1179-6636/work/64361136
dc.description.abstractSummary Alternating contractions of antagonistic muscle groups during locomotion are generated by spinal “half-center” networks coupled in antiphase by reciprocal inhibition. It is widely thought that reciprocal inhibition only coordinates the activity of these muscles. We have devised two methods to rapidly and selectively silence neurons on just one side of Xenopus tadpole spinal cord and hindbrain, which generate swimming rhythms. Silencing activity on one side led to rapid cessation of activity on the other side. Analyses reveal that this resulted from the depression of reciprocal inhibition connecting the two sides. Although critical neurons in intact tadpoles are capable of pacemaker firing individually, an effect that could support motor rhythms without inhibition, the swimming network itself requires ∼23 min to regain rhythmic activity after blocking inhibition pharmacologically, implying some homeostatic changes. We conclude therefore that reciprocal inhibition is critical for the generation of normal locomotor rhythm.
dc.rightsThis is an open access article Copyright © 2013 Elsevier Inc. made available in accordance with publisher policy.en
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleFast silencing reveals a lost role for reciprocal inhibition in locomotionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record