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dc.contributor.authorDimova, Evgeniya G
dc.contributor.authorBryant, Peter Edward
dc.contributor.authorChankova, Stephka G
dc.date.accessioned2013-01-10T12:01:01Z
dc.date.available2013-01-10T12:01:01Z
dc.date.issued2008
dc.identifier.citationDimova , E G , Bryant , P E & Chankova , S G 2008 , ' "Adaptive response" - some underlying mechanisms and open questions ' , Genetics and Molecular Biology , vol. 31 , no. 2 , pp. 396-408 . https://doi.org/10.1590/S1415-47572008000300002en
dc.identifier.issn1415-4757
dc.identifier.otherPURE: 403912
dc.identifier.otherPURE UUID: 08c6d9b3-fbe9-42e3-b41c-ad9cbfaf0f83
dc.identifier.otherWOS: 000256957500002
dc.identifier.otherScopus: 46649112964
dc.identifier.urihttps://hdl.handle.net/10023/3327
dc.description.abstractOrganisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One of them is induced radioresistance or adaptive response. The adaptive response could be considered as a nonspecific phenomenon in which exposure to minimal stress could result in increased resistance to higher levels of the same or to other types of stress some hours later. A better understanding of the molecular mechanism underlying the adaptive response may lead to an improvement of cancer treatment, risk assessment and risk management strategies, radiation protection, e. g. of astronauts during long-term space flights. In this mini-review we discuss some open questions and the probable underlying mechanisms involved in adaptive response: the transcription of many genes and the activation of numerous signaling pathways that trigger cell defenses - DNA repair systems, induction of proteins synthesis, enhanced detoxification of free radicals and antioxidant production.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Biologyen
dc.rightsCopyright © 2008, Sociedade Brasileira de Genética. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAdaptive responseen
dc.subjectOxidative stressen
dc.subjectDNA repair up-regulationen
dc.subjectDNA-binding proteinsen
dc.subjectAntioxidant defense systemen
dc.subjectLow-dose radiationen
dc.subjectPeripheral-blood lympPEROXIDE INDUCES PROTECTIONhocytesen
dc.subjectPeroxide induces protectionen
dc.subjectMethyl mercuric-chlorideen
dc.subjectDouble-strand breaksen
dc.subjectNuclear-power-planten
dc.subjectInduced DNA-damageen
dc.subjectHamster V79 cellsen
dc.subjectIonizing-radiationen
dc.subjectChlamydomonas-reinhardtiien
dc.subjectQH426 Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH426en
dc.title"Adaptive response" - some underlying mechanisms and open questionsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1590/S1415-47572008000300002
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=46649112964&partnerID=8YFLogxKen


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