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dc.contributor.authorKoeser, Claudio U.
dc.contributor.authorEllington, Matthew J.
dc.contributor.authorCartwright, Edward J. P.
dc.contributor.authorGillespie, Stephen H.
dc.contributor.authorBrown, Nicholas M.
dc.contributor.authorFarrington, Mark
dc.contributor.authorHolden, Matthew T. G.
dc.contributor.authorDougan, Gordon
dc.contributor.authorBentley, Stephen D.
dc.contributor.authorParkhill, Julian
dc.contributor.authorPeacock, Sharon J.
dc.date.accessioned2012-12-14T10:31:01Z
dc.date.available2012-12-14T10:31:01Z
dc.date.issued2012-08-02
dc.identifier.citationKoeser , C U , Ellington , M J , Cartwright , E J P , Gillespie , S H , Brown , N M , Farrington , M , Holden , M T G , Dougan , G , Bentley , S D , Parkhill , J & Peacock , S J 2012 , ' Routine use of microbial whole genome sequencing in diagnostic and public health microbiology ' PLoS Pathogens , vol. 8 , no. 8 , e1002824 . https://doi.org/10.1371/journal.ppat.1002824en
dc.identifier.issn1553-7374
dc.identifier.otherPURE: 41247430
dc.identifier.otherPURE UUID: 218ecadd-edfc-4e7f-8787-6a38d303f9f9
dc.identifier.otherWOS: 000308558000008
dc.identifier.otherScopus: 84866148001
dc.identifier.otherORCID: /0000-0001-6537-7712/work/39477856
dc.identifier.urihttp://hdl.handle.net/10023/3290
dc.descriptionThis work is partly supported by funding from the Medical Research Council, the European Developing Country Clinical Trials Partnership, the Global Alliance for TB Drug Development, and the European Union.en
dc.description.abstractWhole genome sequencing (WGS) promises to be transformative for the practice of clinical microbiology, and the rapidly falling cost and turnaround time mean that this will become a viable technology in diagnostic and reference laboratories in the near future. The objective of this article is to consider at a very practical level where, in the context of a modern diagnostic microbiology laboratory, WGS might be cost-effective compared to current alternatives. We propose that molecular epidemiology performed for surveillance and outbreak investigation and genotypic antimicrobial susceptibility testing for microbes that are difficult to grow represent the most immediate areas for application of WGS, and discuss the technical and infrastructure requirements for this to be implemented.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.rights© Köser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectQR Microbiologyen
dc.subject.lccRA0421en
dc.subject.lccQRen
dc.titleRoutine use of microbial whole genome sequencing in diagnostic and public health microbiologyen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Gillespie Groupen
dc.contributor.institutionUniversity of St Andrews.Global Health Implementation Groupen
dc.contributor.institutionUniversity of St Andrews.Infection Groupen
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1002824
dc.description.statusPeer revieweden


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