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dc.contributor.authorGardiner, Anastasia
dc.contributor.authorBarker, Daniel
dc.contributor.authorButlin, Roger K.
dc.contributor.authorJordan, William C.
dc.contributor.authorRitchie, Michael G.
dc.identifier.citationGardiner , A , Barker , D , Butlin , R K , Jordan , W C & Ritchie , M G 2008 , ' Evolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophila ' , PLoS One , vol. 3 , no. 1 , e1513 .
dc.identifier.otherPURE: 2337877
dc.identifier.otherPURE UUID: 8e6d5ca6-9647-4c05-8c69-f27559d42db2
dc.identifier.otherWOS: 000260504200025
dc.identifier.otherScopus: 45149130322
dc.identifier.otherORCID: /0000-0001-7913-8675/work/46761163
dc.description.abstractBackground. Gene families typically evolve by gene duplication followed by the adoption of new or altered gene functions. A different way to evolve new but related functions is alternative splicing of existing exons of a complex gene. The chemosensory gene families of animals are characterised by numerous loci of related function. Alternative splicing has only rarely been reported in chemosensory loci, for example in 5 out of around 120 loci in Drosophila melanogaster. The gustatory receptor gene Gr39a has four large exons that are alternatively spliced with three small conserved exons. Recently the genome sequences of eleven additional species of Drosophila have become available allowing us to examine variation in the structure of the Gr39a locus across a wide phylogenetic range of fly species. Methodology/Principal Findings. We describe a fifth exon and show that the locus has a complex evolutionary history with several duplications, pseudogenisations and losses of exons. PAML analyses suggested that the whole gene has a history of purifying selection, although this was less strong in exons which underwent duplication. Conclusions/Significance. Estimates of functional divergence between exons were similar in magnitude to functional divergence between duplicated genes, suggesting that exon divergence is broadly equivalent to gene duplication.
dc.relation.ispartofPLoS Oneen
dc.rights© 2008 Gardiner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectQH426 Geneticsen
dc.titleEvolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophilaen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Evolution, Genes and Genomicsen
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.description.statusPeer revieweden

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