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dc.contributor.authorGardiner, Anastasia
dc.contributor.authorBarker, Daniel
dc.contributor.authorButlin, Roger K.
dc.contributor.authorJordan, William C.
dc.contributor.authorRitchie, Michael G.
dc.date.accessioned2012-11-27T16:01:05Z
dc.date.available2012-11-27T16:01:05Z
dc.date.issued2008-01-30
dc.identifier2337877
dc.identifier8e6d5ca6-9647-4c05-8c69-f27559d42db2
dc.identifier000260504200025
dc.identifier45149130322
dc.identifier.citationGardiner , A , Barker , D , Butlin , R K , Jordan , W C & Ritchie , M G 2008 , ' Evolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophila ' , PLoS One , vol. 3 , no. 1 , e1513 . https://doi.org/10.1371/journal.pone.0001513en
dc.identifier.issn1932-6203
dc.identifier.otherORCID: /0000-0001-7913-8675/work/46761163
dc.identifier.urihttps://hdl.handle.net/10023/3274
dc.description.abstractBackground. Gene families typically evolve by gene duplication followed by the adoption of new or altered gene functions. A different way to evolve new but related functions is alternative splicing of existing exons of a complex gene. The chemosensory gene families of animals are characterised by numerous loci of related function. Alternative splicing has only rarely been reported in chemosensory loci, for example in 5 out of around 120 loci in Drosophila melanogaster. The gustatory receptor gene Gr39a has four large exons that are alternatively spliced with three small conserved exons. Recently the genome sequences of eleven additional species of Drosophila have become available allowing us to examine variation in the structure of the Gr39a locus across a wide phylogenetic range of fly species. Methodology/Principal Findings. We describe a fifth exon and show that the locus has a complex evolutionary history with several duplications, pseudogenisations and losses of exons. PAML analyses suggested that the whole gene has a history of purifying selection, although this was less strong in exons which underwent duplication. Conclusions/Significance. Estimates of functional divergence between exons were similar in magnitude to functional divergence between duplicated genes, suggesting that exon divergence is broadly equivalent to gene duplication.
dc.format.extent7
dc.format.extent317307
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.subjectQH426 Geneticsen
dc.subject.lccQH426en
dc.titleEvolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophilaen
dc.typeJournal articleen
dc.contributor.sponsorNERCen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Evolution, Genes and Genomicsen
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.identifier.doi10.1371/journal.pone.0001513
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=45149130322&partnerID=8YFLogxKen
dc.identifier.grantnumberNE/C003187/1en


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