Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorJaeger, Antonio
dc.contributor.authorSelmeczy, Diana
dc.contributor.authorO'Connor, Akira Robert
dc.contributor.authorDiaz, Michael
dc.contributor.authorDobbins, Ian
dc.date.accessioned2012-11-08T12:31:04Z
dc.date.available2012-11-08T12:31:04Z
dc.date.issued2012-12
dc.identifier.citationJaeger , A , Selmeczy , D , O'Connor , A R , Diaz , M & Dobbins , I 2012 , ' Prefrontal cortex contributions to controlled memory judgment : fMRI evidence from adolescents and young adults ' , Neuropsychologia , vol. 50 , no. 14 , pp. 3745-3756 . https://doi.org/10.1016/j.neuropsychologia.2012.10.022en
dc.identifier.issn0028-3932
dc.identifier.otherPURE: 32424258
dc.identifier.otherPURE UUID: 212cef4e-6ea3-40f8-a749-81a08b101492
dc.identifier.otherWOS: 000313142700059
dc.identifier.otherScopus: 84869881165
dc.identifier.otherORCID: /0000-0002-7943-5183/work/34028971
dc.identifier.urihttps://hdl.handle.net/10023/3243
dc.description.abstractCortical regions supporting cognitive control and memory judgment are structurally immature in adolescents. Here we studied adolescents (13-15 y.o.) and young adults (20-22 y.o.) using a recognition memory paradigm that modulates cognitive control demands through cues that probabilistically forecast memory probe status. Behaviorally, adolescence was associated with quicker responding in the presence of invalid cues compared to young adulthood. FMRI data demonstrated that while both groups increasingly activated posterior dorsolateral prefrontal (dlPFC), midline, and lateral parietal regions for invalidly compared to validly cued trials, this differential invalid cueing response ended sooner in adolescents, consistent with their generally quicker responding on cued trials. Critically, dlPFC also demonstrated reversed brain-behavior associations across the groups. Increased mean dlPFC activation during invalid cueing was linked to improved performance in young adults, whereas increases within adolescents were linked to impaired performance. Resting state connectivity analysis revealed greater connectivity between dlPFC and episodic retrieval linked regions in young adults relative to adolescents. These data demonstrate that the functional interpretation of dlPFC activation hinges on its physical maturation and suggest that the pattern of behavioral and neural response in adolescents reflects different functional integration of cognitive control and memory systems.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofNeuropsychologiaen
dc.rightsThis is an author version of this work. The published version (c) 2012 Elsevier Ltd is available from http://www.sciencedirect.comen
dc.subjectAdolescenceen
dc.subjectCueingen
dc.subjectDevelopmenten
dc.subjectMemoryen
dc.subjectRecognitionen
dc.subjectBF Psychologyen
dc.subject.lccBFen
dc.titlePrefrontal cortex contributions to controlled memory judgment : fMRI evidence from adolescents and young adultsen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1016/j.neuropsychologia.2012.10.022
dc.description.statusPeer revieweden


This item appears in the following Collection(s)

Show simple item record