Bedaquiline: what might the future hold?
Abstract
Tuberculosis drug development has stagnated for decades, so the recent availability of bedaquiline is welcome. Bedaquiline-containing regimens, now the first-line therapy recommended by WHO, have transformed the treatment of drug-resistant tuberculosis, offering safer and more effective oral treatment options. However, key obstacles need to be overcome to ensure global access and prevent the rapid development of resistance against this promising class of drugs. In this Personal View, building on an international workshop held in 2023, we evaluate the current evidence and suggest possible ways forward, recognising the tension between increasing use and slowing the rise of resistance. We also discuss problems in accessing bedaquiline-containing regimens, the potential widening of their use beyond drug-resistant tuberculosis, and lessons for utilising new drugs as they are developed.
Citation
Shaw , E S , Stoker , N G , Potter , J L , Claassen , H , Leslie , A , Tweed , C D , Chiang , C-Y , Conradie , F , Esmail , H , Lange , C , Pinto , L , Rucsineanu , O , Sloan , D J , Theron , G , Tisile , P , Voo , T C , Warren , R M , Lebina , L & Lipman , M 2024 , ' Bedaquiline: what might the future hold? ' , The Lancet Microbe , vol. In Press , 100909 . https://doi.org/10.1016/S2666-5247(24)00149-6
Publication
The Lancet Microbe
Status
Peer reviewed
ISSN
2666-5247Type
Journal article
Description
Funding: We would like to acknowledge the following who contributed towards publication costs: (1) Africa Health Research Institute supported by Wellcome (Grant number Wellcome Strategic Core award: 227167/A/23/Z). (2) CL was supported by the German Center of Infection Research (DZIF) under agreement TTU-TB 02.709. (3) CYC was supported by Wan Fang Hospital, Taipei Medical University. (4) DJS was supported by University of St Andrews. (5) LP was supported by PD Hinduja Hospital and Medical Research Centre, Mumbai. (6) ML was supported by The Royal Free Charity.Collections
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