Files in this item
HEX17(Neumifil) : an intranasal respiratory biotherapeutic with broad-acting antiviral activity
Item metadata
dc.contributor.author | Potter, Jane A | |
dc.contributor.author | Aitken, Angus | |
dc.contributor.author | Yang, Lei | |
dc.contributor.author | Hill, Jennifer | |
dc.contributor.author | Tortajada, Antoni | |
dc.contributor.author | Hurwitz, Julia L | |
dc.contributor.author | Jones, Bart G | |
dc.contributor.author | Alias, Nadiawati | |
dc.contributor.author | Zhou, Mingkui | |
dc.contributor.author | Connaris, Helen | |
dc.date.accessioned | 2024-07-16T09:30:24Z | |
dc.date.available | 2024-07-16T09:30:24Z | |
dc.date.issued | 2024-08 | |
dc.identifier | 305457719 | |
dc.identifier | 8a920d31-a8ed-4e28-b66c-cd08966edd0b | |
dc.identifier | 38914284 | |
dc.identifier | 85197482321 | |
dc.identifier.citation | Potter , J A , Aitken , A , Yang , L , Hill , J , Tortajada , A , Hurwitz , J L , Jones , B G , Alias , N , Zhou , M & Connaris , H 2024 , ' HEX17(Neumifil) : an intranasal respiratory biotherapeutic with broad-acting antiviral activity ' , Antiviral Research , vol. 228 , 105945 . https://doi.org/10.1016/j.antiviral.2024.105945 | en |
dc.identifier.issn | 0166-3542 | |
dc.identifier.other | Jisc: 2094319 | |
dc.identifier.other | pii: S0166-3542(24)00154-2 | |
dc.identifier.uri | https://hdl.handle.net/10023/30182 | |
dc.description | Funding: This research has been funded by Pneumagen Ltd. | en |
dc.description.abstract | Broad-acting antiviral strategies to prevent respiratory tract infections are urgently required. Emerging or re-emerging viral diseases caused by new or genetic variants of viruses such as influenza viruses (IFVs), respiratory syncytial viruses (RSVs), human rhinoviruses (HRVs), parainfluenza viruses (PIVs) or coronaviruses (CoVs), pose a severe threat to human health, particularly in the very young or old, or in those with pre-existing respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD). Although vaccines remain a key component in controlling and preventing viral infections, they are unable to provide broad-spectrum protection against recurring seasonal infections or newly emerging threats. HEX17 (aka Neumifil), is a first-in-class protein-based antiviral prophylactic for respiratory viral infections. HEX17 consists of a hexavalent carbohydrate-binding module (CBM) with high affinity to sialic acids, which are typically present on terminating branches of glycans on viral cellular receptors. This allows HEX17 to block virus engagement of host receptors and inhibit infection of a wide range of viral pathogens and their variants with reduced risk of antiviral resistance. As described herein, HEX17 has demonstrated broad-spectrum efficacy against respiratory viral pathogens including IFV, RSV, CoV and HRV in multiple in vivo and in vitro studies. In addition, HEX17 can be easily administered via an intranasal spray and is currently undergoing clinical trials. | |
dc.format.extent | 9 | |
dc.format.extent | 3301892 | |
dc.language.iso | eng | |
dc.relation.ispartof | Antiviral Research | en |
dc.subject | Broad-spectrum antiviral | en |
dc.subject | Respiratory syncytial virus | en |
dc.subject | Rhinovirus | en |
dc.subject | Influenza | en |
dc.subject | Carbohydrate-binding module | en |
dc.subject | Coronavirus | en |
dc.subject | QR355 Virology | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QR355 | en |
dc.title | HEX17(Neumifil) : an intranasal respiratory biotherapeutic with broad-acting antiviral activity | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. Centre for Ancient Environmental Studies | en |
dc.identifier.doi | 10.1016/j.antiviral.2024.105945 | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.