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Health economic evaluation of lung cancer screening using a 2 diagnostic blood test : the Early detection of Cancer of the Lung 3 Scotland (ECLS)
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dc.contributor.author | Robles-Zurita, Jose Antonio | |
dc.contributor.author | McMeekin, Nicola | |
dc.contributor.author | Sullivan, Francis | |
dc.contributor.author | Mair, Frances S | |
dc.contributor.author | Briggs, Andrew | |
dc.date.accessioned | 2024-06-21T12:30:08Z | |
dc.date.available | 2024-06-21T12:30:08Z | |
dc.date.issued | 2024-06-18 | |
dc.identifier | 303436152 | |
dc.identifier | a7855fd9-f8a4-41ef-a68b-08b068df7cdc | |
dc.identifier.citation | Robles-Zurita , J A , McMeekin , N , Sullivan , F , Mair , F S & Briggs , A 2024 , ' Health economic evaluation of lung cancer screening using a 2 diagnostic blood test : the Early detection of Cancer of the Lung 3 Scotland (ECLS) ' , Current Oncology , vol. 31 , no. 6 , pp. 3546-3562 . https://doi.org/10.3390/curroncol31060261 | en |
dc.identifier.issn | 1718-7729 | |
dc.identifier.other | ORCID: /0000-0002-6623-4964/work/162168516 | |
dc.identifier.uri | https://hdl.handle.net/10023/30038 | |
dc.description | Funding: Funding for the ECLS study was received from Oncimmune Ltd and the Scottish Government Health & Social Care Directorate of the Chief Scientist Office (CSO). | en |
dc.description.abstract | Background: Diagnostic blood tests have the potential to identify lung cancer in people at high risk. We assessed the cost-effectiveness of a lung cancer screening intervention, using the EarlyCDT®-Lung Test (ECLS) with subsequent X-ray and low-dose chest CT scans (LDCT) for patients with a positive test result, compared to both usual care and LDCT screening for the target population. Methods: We conducted a model-based lifetime analysis from a UK NHS and personal social services perspective. We estimated incremental net monetary benefit (NMB) for the ECLS intervention compared to no screening and to LDCT screening. Results: The incremental NMB of ECLS intervention compared to no screening was GBP 33,179 (95% CI: −GBP 81,396, GBP 147,180) and GBP 140,609 (95% CI: -GBP 36,255, GBP 316,612), respectively, for a cost-effectiveness threshold of GBP 20,000 and GBP 30,000 per quality-adjusted life year. The same figures compared with LDCT screening were GBP 162,095 (95% CI: GBP 52,698, GBP 271,735) and GBP 52,185 (95% CI: −GBP 113,152, GBP 220,711). Conclusions: The ECLS intervention is the most cost-effective screening alternative, with the highest probability of being cost-effective, when compared to no screening or LDCT screening. This result may change with modifications of the parameters, suggesting that the three alternatives considered in the main analysis are potentially cost-effective. | |
dc.format.extent | 17 | |
dc.format.extent | 706324 | |
dc.language.iso | eng | |
dc.relation.ispartof | Current Oncology | en |
dc.subject | Cost-effectiveness | en |
dc.subject | Economic valuation | en |
dc.subject | Lung cancer | en |
dc.subject | Screening | en |
dc.subject | Diagnostic blood test | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | 3rd-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RC0254 | en |
dc.title | Health economic evaluation of lung cancer screening using a 2 diagnostic blood test : the Early detection of Cancer of the Lung 3 Scotland (ECLS) | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews. Population and Behavioural Science Division | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | 10.3390/curroncol31060261 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | https://www.mdpi.com/1718-7729/31/6/261 | en |
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