Files in this item
Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent
Item metadata
dc.contributor.author | Pascall, David J. | |
dc.contributor.author | Vink, Elen | |
dc.contributor.author | Blacow, Rachel | |
dc.contributor.author | Bulteel, Naomi | |
dc.contributor.author | Campbell, Alasdair | |
dc.contributor.author | Campbell, Robyn | |
dc.contributor.author | Clifford, Sarah | |
dc.contributor.author | Davis, Chris | |
dc.contributor.author | da Silva Filipe, Ana | |
dc.contributor.author | El Sakka, Noha | |
dc.contributor.author | Fjodorova, Ludmila | |
dc.contributor.author | Forrest, Ruth | |
dc.contributor.author | Goldstein, Emily | |
dc.contributor.author | Gunson, Rory | |
dc.contributor.author | Haughney, John | |
dc.contributor.author | Holden, Matthew T.G. | |
dc.contributor.author | Honour, Patrick | |
dc.contributor.author | Hughes, Joseph | |
dc.contributor.author | James, Edward | |
dc.contributor.author | Lewis, Tim | |
dc.contributor.author | MacLean, Oscar | |
dc.contributor.author | McHugh, Martin | |
dc.contributor.author | Mollett, Guy | |
dc.contributor.author | Nyberg, Tommy | |
dc.contributor.author | Onishi, Yusuke | |
dc.contributor.author | Parcell, Ben | |
dc.contributor.author | Ray, Surajit | |
dc.contributor.author | Robertson, David L. | |
dc.contributor.author | Seaman, Shaun R. | |
dc.contributor.author | Shabaan, Sharif | |
dc.contributor.author | Shepherd, James G. | |
dc.contributor.author | Smollett, Katherine | |
dc.contributor.author | Templeton, Kate | |
dc.contributor.author | Wastnedge, Elizabeth | |
dc.contributor.author | Wilkie, Craig | |
dc.contributor.author | Williams, Thomas | |
dc.contributor.author | The COVID-19 Genomics UK (COG-UK) Consortium | |
dc.contributor.author | Thomson, Emma C. | |
dc.date.accessioned | 2024-05-31T23:39:26Z | |
dc.date.available | 2024-05-31T23:39:26Z | |
dc.date.issued | 2023-08-01 | |
dc.identifier | 287060967 | |
dc.identifier | d348840a-7a53-4c0c-93e8-44c901b37bbf | |
dc.identifier | 85163078778 | |
dc.identifier.citation | Pascall , D J , Vink , E , Blacow , R , Bulteel , N , Campbell , A , Campbell , R , Clifford , S , Davis , C , da Silva Filipe , A , El Sakka , N , Fjodorova , L , Forrest , R , Goldstein , E , Gunson , R , Haughney , J , Holden , M T G , Honour , P , Hughes , J , James , E , Lewis , T , MacLean , O , McHugh , M , Mollett , G , Nyberg , T , Onishi , Y , Parcell , B , Ray , S , Robertson , D L , Seaman , S R , Shabaan , S , Shepherd , J G , Smollett , K , Templeton , K , Wastnedge , E , Wilkie , C , Williams , T , The COVID-19 Genomics UK (COG-UK) Consortium & Thomson , E C 2023 , ' Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent ' , Journal of Infection , vol. 87 , no. 2 , pp. 128-135 . https://doi.org/10.1016/j.jinf.2023.05.019 | en |
dc.identifier.issn | 0163-4453 | |
dc.identifier.other | RIS: urn:20F5CBE4FFBE86703B223DB54FAEDF19 | |
dc.identifier.other | ORCID: /0000-0002-4958-2166/work/137915492 | |
dc.identifier.uri | https://hdl.handle.net/10023/29972 | |
dc.description | Funding: This work was supported by UKRI through the JUNIPER consortium (grant number MR/V038613/1, https://maths.org/juniper/); the Medical Research Council (MRC) (grant number MC UU 12014/12, grant number MC UU 00002/11, https://www.ukri.org/councils/mrc/); the G2P-UK National Virology Consortium (grant number MR/W005611/1, https://www.ukri.org). | en |
dc.description.abstract | Objectives To determine how the intrinsic severity of successively dominant SARS-CoV-2 variants changed over the course of the pandemic. Methods A retrospective cohort analysis in the NHS Greater Glasgow and Clyde (NHS GGC) Health Board. All sequenced non-nosocomial adult COVID-19 cases in NHS GGC with relevant SARS-CoV-2 lineages (B.1.177/Alpha, Alpha/Delta, AY.4.2 Delta/non-AY.4.2 Delta, non-AY.4.2 Delta/Omicron, and BA.1 Omicron/BA.2 Omicron) during analysis periods were included. Outcome measures were hospital admission, ICU admission, or death within 28 days of positive COVID-19 test. We report the cumulative odds ratio; the ratio of the odds that an individual experiences a severity event of a given level vs all lower severity levels for the resident and the replacement variant after adjustment. Results After adjustment for covariates, the cumulative odds ratio was 1.51 (95% CI: 1.08-2.11) for Alpha versus B.1.177, 2.09 (95% CI: 1.42-3.08) for Delta versus Alpha, 0.99 (95% CI: 0.76-1.27) for AY.4.2 Delta versus non-AY.4.2 Delta, 0.49 (95% CI: 0.22-1.06) for Omicron versus non-AY.4.2 Delta, and 0.86 (95% CI: 0.68-1.09) for BA.2 Omicron versus BA.1 Omicron. Conclusions The direction of change in intrinsic severity between successively emerging SARS-CoV-2 variants was inconsistent, reminding us that the intrinsic severity of future SARS-CoV-2 variants remains uncertain. | |
dc.format.extent | 8 | |
dc.format.extent | 190461 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Infection | en |
dc.subject | Intrinsic severity | en |
dc.subject | COVID-19 | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | Alpha variant | en |
dc.subject | Delta variant | en |
dc.subject | Omicron variant | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | 3rd-DAS | en |
dc.subject | MCC | en |
dc.subject | AC | en |
dc.subject.lcc | RA0421 | en |
dc.title | Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. St Andrews Bioinformatics Unit | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.identifier.doi | 10.1016/j.jinf.2023.05.019 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2024-06-01 |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.