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dc.contributor.authorYoung, Adam M. H.
dc.contributor.authorCampbell, Elaine C.
dc.contributor.authorLynch, Sarah
dc.contributor.authorDunn, Malcolm H.
dc.contributor.authorPowis, Simon J.
dc.contributor.authorSuckling, John
dc.date.accessioned2012-07-13T14:01:02Z
dc.date.available2012-07-13T14:01:02Z
dc.date.issued2012-06-11
dc.identifier.citationYoung , A M H , Campbell , E C , Lynch , S , Dunn , M H , Powis , S J & Suckling , J 2012 , ' Regional susceptibility to TNF-alpha induction of murine brain inflammation via classical IKK/NF-kappa B signalling ' , PLoS One , vol. 7 , no. 6 , e39049 , pp. - . https://doi.org/10.1371/journal.pone.0039049en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 23943024
dc.identifier.otherPURE UUID: 151c71b8-e712-4846-84ad-af6d815b72d4
dc.identifier.otherWOS: 000305337600067
dc.identifier.otherScopus: 84862224791
dc.identifier.otherORCID: /0000-0003-4218-2984/work/60195309
dc.identifier.urihttp://hdl.handle.net/10023/2984
dc.description.abstractIt is becoming clear that inflammation plays a significant role in a number of neurological and psychiatric conditions. Post mortem brain samples in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia and most recently autism spectrum condition, all exhibit neuroglial activation and inflammatory markers within the CSF. Many questions remain about the underlying molecular mechanisms. By adding the pro-inflammatory cytokine, TNF-alpha, to mouse brain tissue we demonstrated that the frontal lobes and temporal region, areas involved in higher functions such as memory and learning, are most susceptible to cytokine-induced inflammation via the NF-kappa B signalling pathway. We observed direct correlations between the volumetric increase and molecular expression indicating that therapeutic targets in these lobes may require different approaches when treating conditions with a central neuroinflammatory component.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.rights© 2012 Young et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectQR180 Immunologyen
dc.subject.lccQR180en
dc.titleRegional susceptibility to TNF-alpha induction of murine brain inflammation via classical IKK/NF-kappa B signallingen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.Office of the Principalen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0039049
dc.description.statusPeer revieweden


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