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Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L
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dc.contributor.author | Urbański, Arkadiusz | |
dc.contributor.author | Johnston, Paul | |
dc.contributor.author | Bittermann, Elisa | |
dc.contributor.author | Keshavarz, Maryam | |
dc.contributor.author | Paris, Véronique | |
dc.contributor.author | Walkowiak-Nowicka, Karolina | |
dc.contributor.author | Konopińska, Natalia | |
dc.contributor.author | Marciniak, Paweł | |
dc.contributor.author | Rolff, Jens | |
dc.date.accessioned | 2024-03-27T11:30:17Z | |
dc.date.available | 2024-03-27T11:30:17Z | |
dc.date.issued | 2022-10-14 | |
dc.identifier | 300474680 | |
dc.identifier | 3cd243fa-8e8d-4ca2-9675-7b1205fbbce0 | |
dc.identifier | 36241888 | |
dc.identifier | 85140003602 | |
dc.identifier.citation | Urbański , A , Johnston , P , Bittermann , E , Keshavarz , M , Paris , V , Walkowiak-Nowicka , K , Konopińska , N , Marciniak , P & Rolff , J 2022 , ' Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L ' , Scientific Reports , vol. 12 , 17277 . https://doi.org/10.1038/s41598-022-21605-6 | en |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | PubMedCentral: PMC9568666 | |
dc.identifier.other | ORCID: /0000-0002-8651-4488/work/157579121 | |
dc.identifier.uri | https://hdl.handle.net/10023/29564 | |
dc.description | The research was partially supported by Grant No. 2021/41/B/NZ9/01054 from the National Science Centre (Poland). AU was supported by a scholarship from the Polish National Agency for Academic Exchange (NAWA) within the Bekker Programme, 2019 (personal stipend, PPN/BEK/2019/1/00167), a scholarship from the Deutscher Akademischer Austauschdienst (DAAD) within the program for Research Stays for University Academics and Scientists, 2018 (personal stipend, 91696887), and a scholarship from the Initiative of Excellence, Research University (ID-UB Project), within the International Junior and Senior Exchange, 2021 (personal stipend, 018/07/POB2/0001). The publication fee was supported by the ID-UB Project (040/08/POB2/0010). JR was funded by DFG FOR 5026. | en |
dc.description.abstract | Tachykinins (TKs) are a group of conserved neuropeptides. In insects, tachykinin-related peptides (TRPs) are important modulators of several functions such as nociception and lipid metabolism. Recently, it has become clear that TRPs also play a role in regulating the insect immune system. Here, we report a transcriptomic analysis of changes in the expression levels of immune-related genes in the storage pest Tenebrio molitor after treatment with Tenmo-TRP-7. We tested two concentrations (10-8 and 10-6 M) at two time points, 6 and 24 h post-injection. We found significant changes in the transcript levels of a wide spectrum of immune-related genes. Some changes were observed 6 h after the injection of Tenmo-TRP-7, especially in relation to its putative anti-apoptotic action. Interestingly, 24 h after the injection of 10-8 M Tenmo-TRP-7, most changes were related to the regulation of the cellular response. Applying 10-6 M Tenmo-TRP-7 resulted in the downregulation of genes associated with humoral responses. Injecting Tenmo-TRP-7 did not affect beetle survival but led to a reduction in haemolymph lysozyme-like antibacterial activity, consistent with the transcriptomic data. The results confirmed the immunomodulatory role of TRP and shed new light on the functional homology between TRPs and TKs. | |
dc.format.extent | 19 | |
dc.format.extent | 8762441 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | en |
dc.subject | Animals | en |
dc.subject | Anti-Bacterial Agents/metabolism | en |
dc.subject | Coleoptera/physiology | en |
dc.subject | Gene Expression | en |
dc.subject | Muramidase/metabolism | en |
dc.subject | Neuropeptides/genetics | en |
dc.subject | Tachykinins/genetics | en |
dc.subject | Tenebrio/metabolism | en |
dc.subject | DAS | en |
dc.title | Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | 10.1038/s41598-022-21605-6 | |
dc.description.status | Peer reviewed | en |
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