Files in this item
Genomic evolution shapes prostate cancer disease type
Item metadata
dc.contributor.author | CRUK-ICGC Prostate Group | |
dc.contributor.author | Woodcock, Dan J | |
dc.contributor.author | Sahli, Atef | |
dc.contributor.author | Teslo, Ruxandra | |
dc.contributor.author | Bhandari, Vinayak | |
dc.contributor.author | Gruber, Andreas J | |
dc.contributor.author | Ziubroniewicz, Aleksandra | |
dc.contributor.author | Gundem, Gunes | |
dc.contributor.author | Xu, Yaobo | |
dc.contributor.author | Butler, Adam | |
dc.contributor.author | Anokian, Ezequiel | |
dc.contributor.author | Pope, Bernard J | |
dc.contributor.author | Jung, Chol-Hee | |
dc.contributor.author | Tarabichi, Maxime | |
dc.contributor.author | Dentro, Stefan C | |
dc.contributor.author | Farmery, J Henry R | |
dc.contributor.author | Van Loo, Peter | |
dc.contributor.author | Warren, Anne Y | |
dc.contributor.author | Gnanapragasam, Vincent | |
dc.contributor.author | Hamdy, Freddie C | |
dc.contributor.author | Bova, G Steven | |
dc.contributor.author | Foster, Christopher S | |
dc.contributor.author | Neal, David E | |
dc.contributor.author | Lu, Yong-Jie | |
dc.contributor.author | Kote-Jarai, Zsofia | |
dc.contributor.author | Bristow, Robert G | |
dc.contributor.author | Boutros, Paul C | |
dc.contributor.author | Costello, Anthony J | |
dc.contributor.author | Corcoran, Niall M | |
dc.contributor.author | Hovens, Christopher M | |
dc.contributor.author | Massie, Charlie E | |
dc.contributor.author | Lynch, Andy G | |
dc.contributor.author | Brewer, Daniel S | |
dc.contributor.author | Eeles, Rosalind A | |
dc.contributor.author | Cooper, Colin S | |
dc.contributor.author | Wedge, David C | |
dc.date.accessioned | 2024-03-14T15:30:09Z | |
dc.date.available | 2024-03-14T15:30:09Z | |
dc.date.issued | 2024-03-13 | |
dc.identifier | 300069797 | |
dc.identifier | 2608d7f1-f04d-4ef9-b6c5-89108c7f4bbd | |
dc.identifier | 38428419 | |
dc.identifier | 85186331848 | |
dc.identifier.citation | CRUK-ICGC Prostate Group , Woodcock , D J , Sahli , A , Teslo , R , Bhandari , V , Gruber , A J , Ziubroniewicz , A , Gundem , G , Xu , Y , Butler , A , Anokian , E , Pope , B J , Jung , C-H , Tarabichi , M , Dentro , S C , Farmery , J H R , Van Loo , P , Warren , A Y , Gnanapragasam , V , Hamdy , F C , Bova , G S , Foster , C S , Neal , D E , Lu , Y-J , Kote-Jarai , Z , Bristow , R G , Boutros , P C , Costello , A J , Corcoran , N M , Hovens , C M , Massie , C E , Lynch , A G , Brewer , D S , Eeles , R A , Cooper , C S & Wedge , D C 2024 , ' Genomic evolution shapes prostate cancer disease type ' , Cell Genomics , vol. 4 , no. 13 , 100511 . https://doi.org/10.1016/j.xgen.2024.100511 | en |
dc.identifier.issn | 2666-979X | |
dc.identifier.other | ORCID: /0000-0002-7876-7338/work/155069488 | |
dc.identifier.uri | https://hdl.handle.net/10023/29492 | |
dc.description | H.R.F. was supported by a Cancer Research UK Programme Grant to Simon Tavaré (C14303/A17197), as, partially, was A.G.L. A.G.L. acknowledges the support of the University of St Andrews. A.G.L. and J.H.R.F. also acknowledge the support of the Cambridge Cancer Research Fund. | en |
dc.description.abstract | The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution. Integrating the results revealed the existence of two distinct types of prostate cancer that arise from divergent evolutionary trajectories, designated as the Canonical and Aalternative evolutionary disease types. We therefore propose the evotype model for prostate cancer evolution wherein Alternative-evotype tumors diverge from those of the Canonical-evotype through the stochastic accumulation of genetic alterations associated with disruptions to androgen receptor DNA binding. Our model unifies many previous molecular observations, providing a powerful new framework to investigate prostate cancer disease progression. | |
dc.format.extent | 31 | |
dc.format.extent | 6500271 | |
dc.language.iso | eng | |
dc.relation.ispartof | Cell Genomics | en |
dc.subject | Prostate cancer | en |
dc.subject | Cancer evolution | en |
dc.subject | Evotype model | en |
dc.subject | Evotypes | en |
dc.subject | AR binding | en |
dc.subject | Ordering | en |
dc.subject | I-PW | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.title | Genomic evolution shapes prostate cancer disease type | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Mathematics and Statistics | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.1016/j.xgen.2024.100511 | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.