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dc.contributor.authorMandal, Suman
dc.contributor.authorBagchi, Arka
dc.contributor.authorBiswas, Arunima
dc.contributor.authorCordes, David B.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorSaha, Nitis Chandra
dc.identifier.citationMandal , S , Bagchi , A , Biswas , A , Cordes , D B , Slawin , A M Z & Saha , N C 2023 , ' Synthesis, spectroscopy and structural elucidation of two new Co II and Ni II complexes of pyrazole derived heterocyclic Schiff base ligand as potential anticancer and photocatalytic agents ' , Chemistry Africa , vol. First Online .
dc.identifier.otherORCID: /0000-0002-9527-6418/work/153977254
dc.identifier.otherORCID: /0000-0002-5366-9168/work/153977363
dc.descriptionDr. Arunima Biswas has received research grant from West Bengal DBT, vide grant no. (676/(Sanc.)/BT/(Estt.)/RD27/2016).en
dc.description.abstractTwo new complexes I and II of general composition, [ML3]X2.nH2O (where, M = CoII and NiII for I and II, respectively, L = MPAFA, X = Br and n = 2) were synthesized from a pyrazolyl Schiff base ligand, MPAFA (L). I and II were characterised through several physico-chemical and spectroscopic techniques, viz., C, H, N analyses, estimation of metal contents, conductance and magnetic susceptibility measurements, IR, electronic and fluorescence spectral studies. Both the reported coordination complexes were cationic in nature and behaved as 1:2 electrolytes. According to IR spectra, each of the MPAFA molecule coordinated to the metal centres via the azomethine nitrogen and the pyrazolyl tertiary nitrogen atoms. Single crystal X-ray diffraction studies of I and II had established a N6 donor set with a distorted octahedral structure for both the cases. Both the complexes exhibited some non-covalent interactions, like π…π stacking, H-bonding contacts etc. L, I and II had also been found to possess fluorescence property. Anticancer activities of L, I and II had been investigated and it was found that both the complexes I and II were stronger cytotoxic agents against the breast cancer cell line MCF7 than the primary ligand system; while all of them (L, I and II) were less toxic against a non-cancerous cell line HEK293. All the compounds had shown potential photocatalytic activity in degrading methylene-blue (MB).
dc.relation.ispartofChemistry Africaen
dc.subjectCoII and NiII complexesen
dc.subjectCrystal structuresen
dc.subjectπ…π stackingen
dc.subjectAnticancer activityen
dc.subjectPhotocatalytic activityen
dc.subjectQD Chemistryen
dc.titleSynthesis, spectroscopy and structural elucidation of two new CoII and NiII complexes of pyrazole derived heterocyclic Schiff base ligand as potential anticancer and photocatalytic agentsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.description.statusPeer revieweden

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