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Ligand-enabled copper-mediated radioiodination of arenes
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dc.contributor.author | McErlain, Holly | |
dc.contributor.author | Andrews, Matthew J. | |
dc.contributor.author | Watson, Allan J. B. | |
dc.contributor.author | Pimlott, Sally L. | |
dc.contributor.author | Sutherland, Andrew | |
dc.date.accessioned | 2024-02-19T12:30:17Z | |
dc.date.available | 2024-02-19T12:30:17Z | |
dc.date.issued | 2024-02-09 | |
dc.identifier | 299396380 | |
dc.identifier | 68c84206-1f4f-4539-8653-665888aa4a8b | |
dc.identifier | 85185832159 | |
dc.identifier.citation | McErlain , H , Andrews , M J , Watson , A J B , Pimlott , S L & Sutherland , A 2024 , ' Ligand-enabled copper-mediated radioiodination of arenes ' , Organic Letters , vol. Ahead of Print . https://doi.org/10.1021/acs.orglett.4c00356 | en |
dc.identifier.issn | 1523-7060 | |
dc.identifier.other | Jisc: 1765652 | |
dc.identifier.other | ORCID: /0000-0002-1582-4286/work/153977707 | |
dc.identifier.uri | https://hdl.handle.net/10023/29289 | |
dc.description.abstract | The discovery of a copper precatalyst that facilitates the key mechanistic steps of arene halodeboronation has allowed a step change in the synthesis of radioiodine-containing arenes. The active precatalyst [Cu(OAc)(phen)2]OAc was shown to perform room temperature radio-iododeboronation of aryl boronic acids with 1–2 mol % loadings and 10 min reaction times. These mild conditions enable particularly clean reactions, as demonstrated with the efficient preparation of the radiopharmaceutical and SPECT tracer, meta-iodobenzylguanidine (MIBG). | |
dc.format.extent | 5 | |
dc.format.extent | 1552444 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic Letters | en |
dc.subject | QD Chemistry | en |
dc.subject | ATC-NDAS | en |
dc.subject.lcc | QD | en |
dc.title | Ligand-enabled copper-mediated radioiodination of arenes | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | The Leverhulme Trust | en |
dc.contributor.sponsor | UK Research and Innovation | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.identifier.doi | 10.1021/acs.orglett.4c00356 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | EP/S027165/1 | en |
dc.identifier.grantnumber | RF-2022-014 | en |
dc.identifier.grantnumber | EP/W007517/1 | en |
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