Files in this item
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial
Item metadata
dc.contributor.author | RECOVERY Collaborative Group | |
dc.contributor.author | Horby, Peter | |
dc.contributor.author | Peto, Leon | |
dc.contributor.author | Staplin, Natalie | |
dc.contributor.author | Campbell, Mark | |
dc.contributor.author | Pessoa-Amorim, Guilherme | |
dc.contributor.author | Mafham, Marion | |
dc.contributor.author | Emberson, Jonathan | |
dc.contributor.author | Stewart, Richard | |
dc.contributor.author | Prudon, Benjamin | |
dc.contributor.author | Uriel, Alison | |
dc.contributor.author | Green, Christopher | |
dc.contributor.author | Dhasmana, Devesh J. | |
dc.contributor.author | Malein, Flora | |
dc.contributor.author | Majumdar, Jaydip | |
dc.contributor.author | Collini, Paul | |
dc.contributor.author | Shurmer, Jack | |
dc.contributor.author | Yates, Bryan | |
dc.contributor.author | Baillie, J. Kenneth | |
dc.contributor.author | Buch, Maya | |
dc.contributor.author | Day, Jeremy | |
dc.contributor.author | Faust, Saul | |
dc.contributor.author | Jaki, Thomas | |
dc.contributor.author | Jeffery, Katie | |
dc.contributor.author | Juszczak, Edmund | |
dc.contributor.author | Knight, Marian | |
dc.contributor.author | Lim, Wei Shen | |
dc.contributor.author | Montgomery, Alan | |
dc.contributor.author | Mumford, Andrew | |
dc.contributor.author | Rowan, Kathryn | |
dc.contributor.author | Thwaites, Guy | |
dc.contributor.author | Haynes, Richard | |
dc.contributor.author | Landray, Martin | |
dc.date.accessioned | 2024-02-02T12:30:01Z | |
dc.date.available | 2024-02-02T12:30:01Z | |
dc.date.issued | 2024-01-31 | |
dc.identifier | 296789827 | |
dc.identifier | ba01b4fd-fdf6-403b-aa76-969deea77ef5 | |
dc.identifier | 85184143675 | |
dc.identifier.citation | RECOVERY Collaborative Group , Horby , P , Peto , L , Staplin , N , Campbell , M , Pessoa-Amorim , G , Mafham , M , Emberson , J , Stewart , R , Prudon , B , Uriel , A , Green , C , Dhasmana , D J , Malein , F , Majumdar , J , Collini , P , Shurmer , J , Yates , B , Baillie , J K , Buch , M , Day , J , Faust , S , Jaki , T , Jeffery , K , Juszczak , E , Knight , M , Lim , W S , Montgomery , A , Mumford , A , Rowan , K , Thwaites , G , Haynes , R & Landray , M 2024 , ' Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial ' , Nature Communications , vol. 15 , 924 . https://doi.org/10.1038/s41467-023-43644-x | en |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/10023/29140 | |
dc.description | Funding: UK Research and Innovation (Medical Research Council) and National Institute for Health and Care Research (Grant ref: MC_PC_19056). | en |
dc.description.abstract | Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome. | |
dc.format.extent | 13 | |
dc.format.extent | 3785179 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Communications | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | E-DAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA0421 | en |
dc.title | Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.1038/s41467-023-43644-x | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.