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Functional host-specific adaptation of the intestinal microbiome in hominids
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dc.contributor.author | Rühlemann, M. C. | |
dc.contributor.author | Bang, C. | |
dc.contributor.author | Gogarten, J. F. | |
dc.contributor.author | Hermes, B. M. | |
dc.contributor.author | Groussin, M. | |
dc.contributor.author | Waschina, S. | |
dc.contributor.author | Poyet, M. | |
dc.contributor.author | Ulrich, M. | |
dc.contributor.author | Akoua-Koffi, C. | |
dc.contributor.author | Deschner, T. | |
dc.contributor.author | Muyembe-Tamfum, J. J. | |
dc.contributor.author | Robbins, M. M. | |
dc.contributor.author | Surbeck, M. | |
dc.contributor.author | Wittig, R. M. | |
dc.contributor.author | Zuberbühler, K. | |
dc.contributor.author | Baines, J. F. | |
dc.contributor.author | Leendertz, F. H. | |
dc.contributor.author | Franke, A. | |
dc.date.accessioned | 2024-01-08T12:30:10Z | |
dc.date.available | 2024-01-08T12:30:10Z | |
dc.date.issued | 2024-01-06 | |
dc.identifier | 298080476 | |
dc.identifier | f0e99f78-fc1f-4257-8b93-000627709196 | |
dc.identifier | 85181503126 | |
dc.identifier.citation | Rühlemann , M C , Bang , C , Gogarten , J F , Hermes , B M , Groussin , M , Waschina , S , Poyet , M , Ulrich , M , Akoua-Koffi , C , Deschner , T , Muyembe-Tamfum , J J , Robbins , M M , Surbeck , M , Wittig , R M , Zuberbühler , K , Baines , J F , Leendertz , F H & Franke , A 2024 , ' Functional host-specific adaptation of the intestinal microbiome in hominids ' , Nature Communications , vol. 15 . https://doi.org/10.1038/s41467-023-44636-7 | en |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | Jisc: 1651844 | |
dc.identifier.other | publisher-id: s41467-023-44636-7 | |
dc.identifier.other | manuscript: 44636 | |
dc.identifier.other | ORCID: /0000-0001-8378-088X/work/150659845 | |
dc.identifier.uri | https://hdl.handle.net/10023/28968 | |
dc.description | Open Access funding enabled and organized by Projekt DEAL. | en |
dc.description.abstract | Fine-scale knowledge of the changes in composition and function of the human gut microbiome compared that of our closest relatives is critical for understanding the evolutionary processes underlying its developmental trajectory. To infer taxonomic and functional changes in the gut microbiome across hominids at different timescales, we perform high-resolution metagenomic-based analyzes of the fecal microbiome from over two hundred samples including diverse human populations, as well as wild-living chimpanzees, bonobos, and gorillas. We find human-associated taxa depleted within non-human apes and patterns of host-specific gut microbiota, suggesting the widespread acquisition of novel microbial clades along the evolutionary divergence of hosts. In contrast, we reveal multiple lines of evidence for a pervasive loss of diversity in human populations in correlation with a high Human Development Index, including evolutionarily conserved clades. Similarly, patterns of co-phylogeny between microbes and hosts are found to be disrupted in humans. Together with identifying individual microbial taxa and functional adaptations that correlate to host phylogeny, these findings offer insights into specific candidates playing a role in the diverging trajectories of the gut microbiome of hominids. We find that repeated horizontal gene transfer and gene loss, as well as the adaptation to transient microaerobic conditions appear to have played a role in the evolution of the human gut microbiome. | |
dc.format.extent | 17 | |
dc.format.extent | 4223714 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Communications | en |
dc.subject | QR Microbiology | en |
dc.subject | DAS | en |
dc.subject.lcc | QR | en |
dc.title | Functional host-specific adaptation of the intestinal microbiome in hominids | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Centre for Social Learning & Cognitive Evolution | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.identifier.doi | https://doi.org/10.1038/s41467-023-44636-7 | |
dc.description.status | Peer reviewed | en |
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