Exploring helical peptides and foldamers for the design of metal helix frameworks : current trends and future perspectives
Abstract
Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).
Citation
Bajpayee , N , Vijayakanth , T , Rencus-Lazar , S , Dasgupta , S , V. Desai , A , Jain , R , Gazit , E & Misra , R 2023 , ' Exploring helical peptides and foldamers for the design of metal helix frameworks : current trends and future perspectives ' , Angewandte Chemie International Edition , vol. 62 , no. 6 , e202214583 . https://doi.org/10.1002/anie.202214583
Publication
Angewandte Chemie International Edition
Status
Peer reviewed
ISSN
1433-7851Type
Journal item
Description
Funding: T.V. thanks Tel Aviv University for the postdoctoral fellowship. E.G. thanks European Research Council PoC project Piezogel (966813) and Ministry of Science and Technology (MOST) Israel-China Program (3-19130). This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499) from the Department of Science and Technology, New Delhi. R. M is also thankful to the National Institute of Pharmaceutical Education and Research, S. A. S. Nagar for providing the research facilities.Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.