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dc.contributor.authorWang, Alec
dc.contributor.authorWalden, Madeline
dc.contributor.authorEttlinger, Romy
dc.contributor.authorKiessling, Fabian
dc.contributor.authorGassensmith, Jeremiah J.
dc.contributor.authorLammers, Twan
dc.contributor.authorWuttke, Stefan
dc.contributor.authorPeña, Quim
dc.date.accessioned2023-11-28T10:30:02Z
dc.date.available2023-11-28T10:30:02Z
dc.date.issued2023-11-21
dc.identifier296886852
dc.identifierf03e7c38-3814-4ecd-91af-320454dd05ca
dc.identifier85177421325
dc.identifier.citationWang , A , Walden , M , Ettlinger , R , Kiessling , F , Gassensmith , J J , Lammers , T , Wuttke , S & Peña , Q 2023 , ' Biomedical metal–organic framework materials : perspectives and challenges ' , Advanced Functional Materials , vol. Early View , 2308589 . https://doi.org/10.1002/adfm.202308589en
dc.identifier.issn1616-301X
dc.identifier.otherJisc: 1511228
dc.identifier.otherpublisher-id: adfm202308589
dc.identifier.urihttps://hdl.handle.net/10023/28774
dc.descriptionThe authors gratefully acknowledge financial support from the German Research Foundation (DFG: LA2937/4-1; SH1223/1-1; SFB 1066; GRK/RTG 2735 (project number 331065168)), the German Federal Ministry of Research and Education (BMBF: Gezielter Wirkstofftransport, PP-TNBC, Project No. 16GW0319K) and the European Research Council (ERC: Meta-Targeting (864121)). The financial support from Welch Foundation (AT-1989-20220331) and from the Human Frontier Science Program (HFSP, within the project RGP0047/2022) are also acknowledged. The authors thank the European Union (European Cooperation in Science and Technology) for the COST Action EU4MOFs (CA22147). Figures were created using BioRender.com.en
dc.description.abstractMetal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural and compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity to retain organic (drug) molecules, metals, and gases, to effectively channel electrons and photons, to survive harsh physiological conditions such as low pH, and even to protect sensitive biomolecules. Extensive preclinical research has been carried out with MOFs to treat several pathologies and, recently, their integration with other biomedical materials such as stents and implants has demonstrated promising performance in regenerative medicine. However, there remains a significant gap between MOF preclinical research and translation into clinically and societally relevant medicinal products. Here, the intrinsic features of MOFs are outlined and their suitability to specific biomedical applications such as detoxification, drug and gas delivery, or as (combination) therapy platforms is discussed. Furthermore, relevant examples of how MOFs have been engineered and evaluated in different medical indications, including cancer, microbial, and inflammatory diseases is described. Finally, the challenges facing their translation into the clinic are critically examined, with the goal of establishing promising research directions and more realistic approaches that can bridge the translational gap of MOFs and MOF‐containing (nano)materials.
dc.format.extent22
dc.format.extent4288294
dc.language.isoeng
dc.relation.ispartofAdvanced Functional Materialsen
dc.subjectPorous materialsen
dc.subjectMetallotherapyen
dc.subjectBiomedicineen
dc.subjectNanoparticlesen
dc.subjectMetal–organic frameworksen
dc.subjectQD Chemistryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQDen
dc.titleBiomedical metal–organic framework materials : perspectives and challengesen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doi10.1002/adfm.202308589
dc.description.statusPeer revieweden


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